发明授权
US06884773B1 Modified hemoglobins, including nitrosylhemoglobins, and uses thereof
失效
修饰的血红蛋白，包括亚硝基血红蛋白，及其用途
- 专利标题： Modified hemoglobins, including nitrosylhemoglobins, and uses thereof
- 专利标题（中）： 修饰的血红蛋白，包括亚硝基血红蛋白，及其用途
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申请号： US08796164申请日： 1997-02-06
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公开(公告)号： US06884773B1公开(公告)日： 2005-04-26
- 发明人: Jonathan S. Stamler , Andrew J. Gow
- 申请人： Jonathan S. Stamler , Andrew J. Gow
- 申请人地址： US NC Durham
- 专利权人： Duke University
- 当前专利权人： Duke University
- 当前专利权人地址： US NC Durham
- 代理机构： Hamilton, Brook, Smith & Reynolds, P.C.
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K31/00 ; A61K31/04 ; A61K31/095 ; A61K31/10 ; A61K31/195 ; A61K35/14 ; A61K35/18 ; A61K38/00 ; A61K38/42 ; A61K45/00 ; A61K47/48 ; A61P7/00 ; A61P7/02 ; A61P7/06 ; A61P9/00 ; A61P9/10 ; A61P11/00 ; A61P33/00 ; A61P33/06 ; A61P39/00 ; A61P39/06 ; C07K14/00 ; C07K14/805 ; C12N5/08 ; G01N21/63 ; G01N21/76 ; G01N33/72
摘要：
Diseases which can be ameliorated by delivery of NO to tissues affected by the disease can be treated by administration of nitrosyl-heme-containing donors of NO, including nitrosylhemoglobin. Nitrosylhemoglobin can be made by the reaction of NO with hemoglobin under certain conditions in which the NO:hemoglobin ratio is critical, and is converted to SNO-Hb under physiological conditions.