利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

101 条记录 (耗时 0.029 秒)

    Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders
    3.
    发明授权
    Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders 有权
    以气体形式肺部输送含NO组的化合物，以治疗呼吸，心脏和血液疾病

    公开(公告)号：US06314956B1

    公开(公告)日：2001-11-13

    申请号：US09390215

    申请日：1999-09-08

    申请人： Jonathan S. Stamler ,  Eric J. Toone ,  Andrew J. Gow

    发明人： Jonathan S. Stamler ,  Eric J. Toone ,  Andrew J. Gow

    IPC分类号： A61M1500

    CPC分类号： C12N5/0641 ,  A61K31/197 ,  A61K31/21 ,  A61K33/00 ,  A61K33/04 ,  A61M2202/0275 ,  A61K2300/00

    摘要： Treatment of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction comprises administering into the lungs as a gas a compound with an NO group which does not form NO2/NOx in the presence of oxygen or reactive oxygen species at body temperature. Treatment of cardiac and blood disorders, e.g., angina, myocardial infarction, heart failure, hypertension, sickle cell disease and clotting disorders, comprises administering into the lungs as a gas, a compound which reacts with cysteine in hemoglobin and/or dissolves in blood and has an NO group which is bound in said compound so that it does not form NO2/NOx in the presence of oxygen or reactive oxygen species at body temperature. Exemplary of the compound administered in each case is ethyl nitrite.

    摘要翻译： 与低氧血症和/或平滑肌收缩相关的肺部疾病的治疗包括在体温下在氧气或活性氧存在的情况下向肺中施用具有NO基团的化合物作为气体，所述NO组不形成NO 2 / NO x。 治疗心脏和血液疾病，例如心绞痛，心肌梗死，心力衰竭，高血压，镰状细胞病和凝血障碍，包括作为气体给予肺，与血红蛋白中的半胱氨酸反应和/或溶解于血液中的化合物和 具有在所述化合物中结合的NO基团，使得其在体温存在氧或活性氧的情况下不形成NO 2 / NO x。 在每种情况下施用的化合物的实例是亚硝酸乙酯。

    USE OF AN AGENT THAT RESTORES TISSUE PERFUSION AND OXYGENATION
    9.
    发明申请
    USE OF AN AGENT THAT RESTORES TISSUE PERFUSION AND OXYGENATION 有权
    使用恢复组织灌注和氧化的药剂

    公开(公告)号：US20120225133A1

    公开(公告)日：2012-09-06

    申请号：US13449932

    申请日：2012-04-18

    申请人： Mark W. Dewhirst ,  Jonathan S. Stamler ,  Timothy J. McMahon ,  Pierre Sonveaux

    发明人： Mark W. Dewhirst ,  Jonathan S. Stamler ,  Timothy J. McMahon ,  Pierre Sonveaux

    IPC分类号： A61K33/00 ,  A61P3/10 ,  A61P9/10 ,  A61P29/00 ,  A61P25/00 ,  A61P35/00 ,  A61P1/16

    CPC分类号： A61K38/1709 ,  A61K31/21 ,  A61K33/00 ,  A61K35/18 ,  A61K38/00 ,  A61K38/42 ,  A61K45/06 ,  A61K47/08 ,  A61K47/16 ,  A61K47/6445 ,  A61K2300/00

    摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.

    摘要翻译： 目前公开的主题提供了在受试者的组织的缺氧区域中增加灌注的方法。 还提供了用于治疗受试者与缺氧相关的疾病和/或病症的方法，用于增加肿瘤对放射和/或化疗治疗的敏感性的方法，用于延迟受试者的肿瘤生长的方法，以及用于抑制受试者的肿瘤血管生长的方法。 在一些实施方案中，本发明公开的方法包括向有需要的受试者施用选自亚硝基化血红蛋白和诱导受试者内源性血红蛋白亚硝基化的试剂的第一组合物和包含高氧气体的第二组合物。 在一些实施方案中，本发明公开的方法还包括用放射治疗，化疗，光动力疗法，免疫治疗或其组合治疗肿瘤。 还提供了可在本公开的方法中使用的可吸入气体。

    Use of an agent that restores tissue perfusion and oxygenation
    10.
    发明授权
    Use of an agent that restores tissue perfusion and oxygenation 有权
    使用恢复组织灌注和氧合的药物

    公开(公告)号：US08198241B2

    公开(公告)日：2012-06-12

    申请号：US12847330

    申请日：2010-07-30

    申请人： Mark W. Dewhirst ,  Jonathan S. Stamler ,  Timothy J. McMahon ,  Pierre Sonveaux

    发明人： Mark W. Dewhirst ,  Jonathan S. Stamler ,  Timothy J. McMahon ,  Pierre Sonveaux

    IPC分类号： A61K38/00 ,  A61K33/00

    CPC分类号： A61K38/1709 ,  A61K31/21 ,  A61K33/00 ,  A61K35/18 ,  A61K38/00 ,  A61K38/42 ,  A61K45/06 ,  A61K47/08 ,  A61K47/16 ,  A61K47/6445 ,  A61K2300/00

    摘要： The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.

    摘要翻译： 目前公开的主题提供了在受试者的组织的缺氧区域中增加灌注的方法。 还提供了用于治疗受试者与缺氧相关的疾病和/或病症的方法，用于增加肿瘤对放射和/或化疗治疗的敏感性的方法，用于延迟受试者的肿瘤生长的方法，以及用于抑制受试者的肿瘤血管生长的方法。 在一些实施方案中，本发明公开的方法包括向有需要的受试者施用选自亚硝基化血红蛋白和诱导受试者内源性血红蛋白亚硝基化的试剂的第一组合物和包含高氧气体的第二组合物。 在一些实施方案中，本发明公开的方法还包括用放射治疗，化疗，光动力疗法，免疫治疗或其组合治疗肿瘤。 还提供了可在本公开的方法中使用的可吸入气体。