发明授权
- 专利标题: Anti-VEGF antibodies
- 专利标题(中): 抗VEGF抗体
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申请号: US08908469申请日: 1997-08-06
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公开(公告)号: US06884879B1公开(公告)日: 2005-04-26
- 发明人: Manuel Baca , James A. Wells
- 申请人: Manuel Baca , James A. Wells
- 申请人地址: US CA South San Francisco
- 专利权人: Genentech, Inc.
- 当前专利权人: Genentech, Inc.
- 当前专利权人地址: US CA South San Francisco
- 代理机构: Genentech, Inc.
- 主分类号: C12N15/02
- IPC分类号: C12N15/02 ; A61K38/00 ; C07K16/18 ; C07K16/22 ; C12P21/08 ; C07H21/04
摘要:
Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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