发明授权
- 专利标题： Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
- 专利标题（中）： 用于治疗良性前列腺增生的芳基取代哌嗪
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申请号： US09526224申请日： 2000-03-15
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公开(公告)号： US06890921B1公开(公告)日： 2005-05-10
- 发明人: Linda Jolliffe , William Murray , Virginia Pulito , Allen Reitz , Xiaobing Li , Linda Mulcahy , Cynthia Maryanoff , Frank Villani
- 申请人： Linda Jolliffe , William Murray , Virginia Pulito , Allen Reitz , Xiaobing Li , Linda Mulcahy , Cynthia Maryanoff , Frank Villani
- 申请人地址： US NJ Raritan
- 专利权人： Ortho-McNeil Pharmaceutical, Inc.
- 当前专利权人： Ortho-McNeil Pharmaceutical, Inc.
- 当前专利权人地址： US NJ Raritan
- 代理商 Laura A. Donnelly
- 主分类号： C07D295/12
- IPC分类号： C07D295/12 ; A61K31/397 ; A61K31/40 ; A61K31/4015 ; A61K31/402 ; A61K31/4025 ; A61K31/445 ; A61K31/496 ; A61K31/55 ; A61P13/08 ; C07D205/08 ; C07D207/12 ; C07D207/26 ; C07D207/27 ; C07D207/28 ; C07D209/44 ; C07D209/48 ; C07D211/40 ; C07D211/76 ; C07D221/20 ; C07D223/10 ; C07D225/02 ; C07D225/08 ; C07D241/04 ; C07D295/08 ; C07D295/13 ; C07D401/12 ; C07D403/12
摘要：
This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
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