发明授权
- 专利标题: Irreversible immobilization of enzymes into polyurethane coatings
- 专利标题(中): 不可逆地将酶固定在聚氨酯涂料中
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申请号: US10202224申请日: 2002-07-24
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公开(公告)号: US06905733B2公开(公告)日: 2005-06-14
- 发明人: Alan J. Russell , Geraldine F. Drevon , Douglas Wicks , Karsten Danielmeier
- 申请人: Alan J. Russell , Geraldine F. Drevon , Douglas Wicks , Karsten Danielmeier
- 申请人地址: US PA Pittsburgh US PA Pittsburgh
- 专利权人: University of Pittsburgh,Bayer Polymers LLC
- 当前专利权人: University of Pittsburgh,Bayer Polymers LLC
- 当前专利权人地址: US PA Pittsburgh US PA Pittsburgh
- 代理机构: Thorp Reed & Armstrong LLP
- 主分类号: G01N27/327
- IPC分类号: G01N27/327 ; C12N11/04 ; C12N11/08 ; B05D3/00
摘要:
This invention provides a method of irreversibly immobilizing an enzyme into polyurethane coatings. This invention also provides for an enzyme-containing coating having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethane coatings in the presence of enzyme has enabled the irreversible attachment of the enzyme to the polymeric matrix. The distribution of immobilized enzyme as well as activity retention are homogeneous within the coating. Decreasing ECC hydrophobicity, via the use of a less hydrophobic polyisocyanate prepolymer during polymerization, significantly enhanced the intrinsic activity of the ECC.