发明授权
US06914064B2 1,4-Disubstituted piperazine derivatives useful as uro-selective α1-adrenoceptor blockers
失效
可用作尿选择性α1-肾上腺素受体阻断剂的1,4-二取代哌嗪衍生物
- 专利标题： 1,4-Disubstituted piperazine derivatives useful as uro-selective α1-adrenoceptor blockers
- 专利标题（中）： 可用作尿选择性α1-肾上腺素受体阻断剂的1,4-二取代哌嗪衍生物
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申请号： US09998115申请日： 2001-11-30
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公开(公告)号： US06914064B2公开(公告)日： 2005-07-05
- 发明人: Nitya Anand , Sanjay Jain , Neelima Sinha , Anita Chugh , Laxminarayan G. Hegde , Jang Bahadur Gupta
- 申请人： Nitya Anand , Sanjay Jain , Neelima Sinha , Anita Chugh , Laxminarayan G. Hegde , Jang Bahadur Gupta
- 申请人地址： IN New Delhi
- 专利权人： Ranbaxy Laboratories Limited
- 当前专利权人： Ranbaxy Laboratories Limited
- 当前专利权人地址： IN New Delhi
- 代理商 Jayadeep R. Deshmukh, Esq.; George E. Heibel, Esq.
- 优先权： IN1097/00 20001130
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; A61P13/08 ; A61P43/00 ; C07D209/48 ; A61K31/496 ; C07D403/06
摘要：
The present invention relates to a novel 1,4-disubstituted piperazine derivatives of Formula I, and their pharmaceutically acceptable acid addition salts having excellent uro-selective α1-adrenoceptor antagonistic activity exceeding those of previously described compounds. The compounds of the present invention hold promise for treating the symptoms of benign prostatic hyperplasia (BPH). The invention also relates to methods for making the novel compounds, pharmaceutical compositions containing the compounds, and method of treating the symptoms of benign prostatic hyperplasia using the compounds.
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