发明授权
US06914151B1 Crystallization processes for the formation of stable crystals of aspartame derivative
失效
用于形成稳定的阿斯巴甜衍生物晶体的结晶过程
- 专利标题: Crystallization processes for the formation of stable crystals of aspartame derivative
- 专利标题(中): 用于形成稳定的阿斯巴甜衍生物晶体的结晶过程
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申请号: US09830159申请日: 1999-11-01
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公开(公告)号: US06914151B1公开(公告)日: 2005-07-05
- 发明人: Shigeru Kawahara , Akihiro Kishishita , Kazutaka Nagashima , Tadashi Takemoto
- 申请人: Shigeru Kawahara , Akihiro Kishishita , Kazutaka Nagashima , Tadashi Takemoto
- 申请人地址: JP Tokyo
- 专利权人: Ajinomoto Co., Inc.
- 当前专利权人: Ajinomoto Co., Inc.
- 当前专利权人地址: JP Tokyo
- 代理机构: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
- 优先权: JP10/310225 19981030; JP10/310226 19981030
- 国际申请: PCT/JP99/06082 WO 19991101
- 国际公布: WO00/26234 WO 20000511
- 主分类号: C07K5/072
- IPC分类号: C07K5/072 ; C07K5/075 ; C07C229/00
摘要:
A crystallization process for forming a stable crystal of N-(3,3-dimethylbutyl)-APM, which comprises using either water or a mixture of water with a lower alcohol as the crystallizing solvent and controlling the crystallization point to 30° C. or above; and another crystallization process therefor, which comprises using either water or a mixture of water with a lower alcohol as the crystallizing solvent and using as the seed crystal a crystal of N-(3,3-dimethylbutyl)-APM exhibiting peculiar peaks of diffracted X-ray at least at diffraction angles (2θ, CuKα ray) of 6.0°, 24.8°, 8.2° and 16.5° to thereby crystallize the above objective crystal preferentially. These crystallization processes enable the constant formation of stable crystals of N-(3,3-dimethylbutyl)-APM at a low cost.