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1.发明授权Crystallization processes for the formation of stable crystals of aspartame derivative 失效用于形成稳定的阿斯巴甜衍生物晶体的结晶过程公开(公告)号：US06914151B1
公开(公告)日：2005-07-05
申请号：US09830159
申请日：1999-11-01
IPC分类号： C07K5/072 , C07K5/075 , C07C229/00
CPC分类号： C07K5/0613
摘要： A crystallization process for forming a stable crystal of N-(3,3-dimethylbutyl)-APM, which comprises using either water or a mixture of water with a lower alcohol as the crystallizing solvent and controlling the crystallization point to 30° C. or above; and another crystallization process therefor, which comprises using either water or a mixture of water with a lower alcohol as the crystallizing solvent and using as the seed crystal a crystal of N-(3,3-dimethylbutyl)-APM exhibiting peculiar peaks of diffracted X-ray at least at diffraction angles (2θ, CuKα ray) of 6.0°, 24.8°, 8.2° and 16.5° to thereby crystallize the above objective crystal preferentially. These crystallization processes enable the constant formation of stable crystals of N-(3,3-dimethylbutyl)-APM at a low cost.
摘要翻译： 用于形成N-（3,3-二甲基丁基）-APM的稳定结晶的结晶方法，其包括使用水或水与低级醇的混合物作为结晶溶剂并将结晶点控制在30℃，或 以上; 和另一种结晶方法，其包括使用水或水与低级醇的混合物作为结晶溶剂，并且使用表现出衍射X的独特峰的N-（3,3-二甲基丁基）-APM晶种作为晶种 至少在6.0°，24.8°，8.2°和16.5°的衍射角（2θ，CuKalpha射线）处，以便优先结晶上述目标晶体。 这些结晶过程使得能够以低成本恒定地形成N-（3,3-二甲基丁基）-APM的稳定晶体。
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公开(公告)号：US06844465B2
公开(公告)日：2005-01-18
申请号：US10160000
申请日：2002-06-04
IPC分类号： C07K5/075 , C07C229/00
CPC分类号： C07K5/0613
摘要： Disclosed in the present application are a method for preparing highly-stable A-type crystals by controlling and maintaining the product temperature of B-type N-(3,3-dimethylbutyl)-APM crystals at 25 to 80° C. under an absolute humidity of 0.203 kg/kg or less environment, thereby effecting crystal transition; and a method for preparing A-type crystals by controlling and maintaining the product temperature of D-type crystals of N-(3,3-dimethylbutyl)-APM at 25 to 80° C. under an absolute humidity of 0.0550 kg/kg or less environment, thereby effecting crystal transition. According to these crystal transition methods, highly stable crystals can be prepared stably and at a low cost.
摘要翻译： 本申请中公开了一种通过控制并保持B型N-（3,3-二甲基丁基）-APM晶体在25至80℃下的产物温度在绝对值下制备高度稳定的A型晶体的方法 湿度为0.203kg / kg以下的环境，从而进行晶体转变; 以及通过在0.05〜50kg / kg的绝对湿度下在25〜80℃下控制并维持N-（3,3-二甲基丁基）-APM的D-型晶体的产物温度来制备A型晶体的方法或 较少的环境，从而进行晶体转变。 根据这些晶体转变方法，可以稳定且低成本地制备高度稳定的晶体。
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公开(公告)号：US06790470B1
公开(公告)日：2004-09-14
申请号：US09708006
申请日：2000-11-08
IPC分类号： A23L1236
CPC分类号： C07K5/06113
摘要： For example, N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine methyl ester (A-type crystal) showing characteristic peaks in diffractive X-ray at diffraction angles (2&thgr;, CuK&agr; ray) of at least 6.0°, 24.8°, 8.2° and 16.5° is dried to its water content below 3% by weight. The crystal thus dried is a novel crystal (C-type crystal) of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine methyl ester excellent in dissolution rate, and when measured by powder X-ray diffractometry, this crystal shows characteristic peaks in diffractive X-ray at diffraction angles (2&thgr;, CuK&agr; ray) of at least 7.1°, 19.8°, 17.3° and 17.7°. The dissolution rate (solubility) of the C-type crystals is further improved by converting the crystals into granules.
摘要翻译： 例如，在衍射角衍射X射线（2θ，CuKalpha射线）中显示特征峰的N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸甲酯（A型晶体） ）至少为6.0°，24.8°，8.2°和16.5°，其水分含量低于3重量％。 这样干燥的晶体是溶解速度优异的N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸甲酯的新晶体（C型晶体），当用粉末 X射线衍射法，该晶体在衍射角（2θ，CuKalpha射线）的衍射X射线中显示出至少7.1°，19.8°，17.3°和17.7°的特征峰。 通过将晶体转化为颗粒，进一步提高了C型晶体的溶解速率（溶解度）。
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公开(公告)号：US06372278B1
公开(公告)日：2002-04-16
申请号：US09707953
申请日：2000-11-08
IPC分类号： A23L1236
CPC分类号： C07K5/06113 , A23L27/32
摘要： One embodiment of the present invention provides a sweetener composition, which includes N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester, and Aspartame, wherein a ratio of the Aspartame to a total amount of the Aspartame and the N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester is in the range of 10 to 99.5% by weight, methods of making and of using. Another embodiment of the present invention provides a method for preparing a sweetener composition, which includes drying an A-type crystal of N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl }-L-phenylalanine 1-methyl ester to obtain a C-type crystal of N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl }-L-phenylalanine 1-methyl ester. Another embodiment of the present invention provides a method for producing a sweetener, which includes admixing N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl }-L-phenylalanine 1-methyl ester with Aspartame, wherein a ratio of the Aspartame to a total amount of the N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl }-L-phenylalanine 1-methyl ester and the Aspartame is in the range of 10 to 99.5% by weight. Another embodiment of the present invention provides a method for improving the dissolution rate of N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl }-L-phenylalanine 1-methyl ester, which includes, prior to dissolving the N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl }-L-phenylalanine 1-methyl ester, admixing the N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl }-L-phenylalanine 1-methyl ester with Aspartame, wherein a ratio of the Aspartame to a total amount of the N-{N-(3,3-dimethylbutyl)-L&agr;-aspartyl}-L-phenylalanine 1-methyl ester and the Aspartame is in the range of 10 to 99.5% by weight.
摘要翻译： 本发明的一个实施方案提供了一种甜味剂组合物，其包括N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯和天冬甜素，其中天冬甜素 至总量的天冬甜素和N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯的重量百分比为10〜99.5重量％ 制作和使用。 本发明的另一个实施方案提供了一种制备甜味剂组合物的方法，其包括将N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲基 得到N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯的C型结晶。 本发明的另一个实施方案提供一种生产甜味剂的方法，其包括将N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯与天冬甜素混合，其中比例 的天冬甜素与总量的N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯和天冬甜素的比例在10至99.5重量％的范围内 。 本发明的另一个实施方案提供了一种改善N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯的溶解速率的方法，其包括在将 N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯，将N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} 具有天冬甜素的L-苯丙氨酸1-甲酯，其中天冬甜素与N- {N-（3,3-二甲基丁基）-Lα-天冬氨酰基} -L-苯丙氨酸1-甲酯和天冬甜精的总量的比例 在10至99.5重量％的范围内。
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5.发明授权公开(公告)号：US06444251B1
公开(公告)日：2002-09-03
申请号：US09594039
申请日：2000-06-15
IPC分类号： A23L1236
CPC分类号： C07K5/06113 , A23L27/32 , C07K5/0613
摘要： A homogeneous sweetener composition containing aspartame (APM) and N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine methyl ester having tasting properties similar to sucrose, can be efficiently produced in high yields and with a high purity by reductive alkylation of APM with an at most equimolar amount 3,3-dimethylbutylaldehyde followed by separating the reducing agent from the liquid reaction mixture, and separating of the precipitated crystals of the sweetener composition.
摘要翻译： 具有与蔗糖相似的品尝性能的含有阿斯巴甜（APM）和N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸甲酯的均匀的甜味剂组合物可以高产率有效地生产， 通过用至多等摩尔量的3,3-二甲基丁醛的APM的还原烷基化，然后从液体反应混合物中分离还原剂，并分离出甜味剂组合物的沉淀的晶体，具有高纯度。
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6.发明授权公开(公告)号：US06613933B1
公开(公告)日：2003-09-02
申请号：US09590690
申请日：2000-06-09
IPC分类号： C07C22900
CPC分类号： C07K5/06113 , A23L27/32 , C07K5/0613
摘要： A process for easily and efficiently separating aspartame (APM) from N-[N-(3,3-dimethylbutyl)-L-(&agr;-aspartyl]-L-phenylalanine methyl ester (APM derivative), and thus separating and purifying the APM and the above-mentioned APM derivative, more specifically the N-(3,3-dimethylbutyl)-APM each at a high purity, which comprises subjecting an aqueous solution containing the APM and the APM derivative, to column chromatography using a nonpolar highly porous polymer based resin.
摘要翻译： 一种从N- [N-（3,3-二甲基丁基）-L-（α-天冬氨酰基）-L-苯丙氨酸甲酯（APM衍生物）中容易且高效分离阿斯巴甜（APM）的方法，从而分离和纯化APM 和上述APM衍生物，更具体地是高纯度的N-（3,3-二甲基丁基）-APM，其包括使含有APM和APM衍生物的水溶液进行柱色谱，使用非极性高度多孔 聚合物基树脂。
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公开(公告)号：US06372279B1
公开(公告)日：2002-04-16
申请号：US09707954
申请日：2000-11-08
IPC分类号： A23L1236
CPC分类号： A23L27/32
摘要： One embodiment of the present invention provides a sweetener composition, which includes a mixture of N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester, and Acesulfame K, wherein a ratio of the Acesulfame K to a total amount of the N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester and the Acesulfame K is in the range of 10 to 97% by weight, methods of making and of using. Another embodiment of the present invention provides a method for preparing a sweetener composition, which includes drying an A-type crystal of N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester to obtain a C-type crystal of N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester. Another embodiment of the present invention provides a method for producing a sweetener, which includes admixing N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester with Acesulfame K, wherein a ratio of the Acesulfame K to a total amount of the N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester and the Acesulfame K is in the range of 10 to 97% by weight. Another embodiment of the present invention provides a method for improving the dissolution rate of N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester, which includes, prior to dissolving the N-{N-(3,3 -dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester, admixing the N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester with Acesulfame K, wherein a ratio of the Acesulfame K to a total amount of the N-{N-(3,3-dimethylbutyl)-L-&agr;-aspartyl}-L-phenylalanine 1-methyl ester and the Acesulfame K is in the range of 10 to 97% by weight.
摘要翻译： 本发明的一个实施方案提供一种甜味剂组合物，其包括N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯和乙酰磺胺酸K的混合物，其中a 乙酰磺胺酸钾与N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯和乙酰磺胺酸钾的总量的比例在10至97的范围内 重量％，制造方法和使用方法。 本发明的另一个实施方案提供了一种制备甜味剂组合物的方法，其包括将N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲基 得到N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯的C型晶体。 本发明的另一个实施方案提供了一种生产甜味剂的方法，其包括将N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯与乙酰磺胺酸K混合，其中 乙酰磺胺酸钾与N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯和乙酰磺胺酸钾的总量的比例在10至97的范围内 重量％。 本发明的另一个实施方案提供了一种改善N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯的溶解速率的方法，其包括在溶解 N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲酯，混合N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} L-苯丙氨酸1-甲酯与乙酰磺胺酸K，其中乙酰磺胺酸钾与N- {N-（3,3-二甲基丁基）-L-α-天冬氨酰基} -L-苯丙氨酸1-甲基酯的总量的比例 酯和丁磺克烷K的重量百分比在10至97％的范围内。
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8.发明授权Mixed crystals comprising aspartame and aspartame derivative and process for producing the same 有权包含阿斯巴甜和阿斯巴甜衍生物的混合晶体及其制备方法公开(公告)号：US06346642B1
公开(公告)日：2002-02-12
申请号：US09591562
申请日：2000-06-13
IPC分类号： C07C22900
CPC分类号： C07K5/06113 , A23L27/32 , C07K5/0613
摘要： There is provided a novel mixed crystal comprising aspartame (APM) and N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine methyl ester, which can be used as a sweetener having considerably improved quality of sweetness, etc. The above mixed crystal can be easily produced industrially by subjecting a solution containing the above-mentioned APM and APM derivative to a crystallizing operation followed by the separation of the mixed crystal thus precipitated.
摘要翻译： 提供了包含阿斯巴甜（APM）和N- [N-（3,3-二甲基丁基）-L-α-天冬氨酰基] -L-苯丙氨酸甲酯的新型混合晶体，其可用作具有显着提高质量的甜味剂 的甜味等。通过使含有上述APM和APM衍生物的溶液进行结晶操作，然后分离如此沉淀的混合晶体，可以在工业上容易地制造上述混合晶体。
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公开(公告)号：US5886966A
公开(公告)日：1999-03-23
申请号：US855252
申请日：1997-05-13
IPC分类号： G11B7/0037 , G11B7/005 , G11B19/28 , G11B33/08 , G11B3/90
CPC分类号： G11B19/28 , G11B33/08 , G11B7/0037 , G11B7/005
摘要： In an optical disk reproducing device capable of rotating an optical disk at a selected one of a plurality of preset linear velocities, vibration or shock of the device is detected during rotation of the disk, and the linear velocity of the disk is determined based on the result of the detection of the vibration or shock to restrain the vibration and shock within a permissible range. A limit rotational velocity above which the vibration or shock is excessive may be determined during a test conducted each time a disk is inserted, and the linear velocity of the disk during reproduction may be determined such that the rotational velocity does not exceed the limit rotational velocity.
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10.发明授权
公开(公告)号：US5493556A
公开(公告)日：1996-02-20
申请号：US191328
申请日：1994-02-03
申请人： Shinichi Aoki , Akihiro Kishishita
发明人： Shinichi Aoki , Akihiro Kishishita
CPC分类号： G11B17/225
摘要： In a multi-disk player having a loading and unloading equipment for selecting an arbitrary disk cassette from a containing portion for containing a plurality of trays each supporting one disk cassette in which a disk-shaped record medium is contained in a cassette case with they being arranged in a lot of upper and lower stages, loading the selected disk cassette into a record playing equipment disposed behind the containing portion and returning the same to its original position in the containing portion from the recording playing equipment after the playing of the disk cassette is terminated,the containing portion has a plurality of ejecting operating means for each releasing a locking function for disk cassette so that the operating means corresponding to an arbitrary disk cassette in the containing portion is operated to eject the disk cassette toward the front of the containing portion.
摘要翻译： 在具有装载和卸载设备的多盘播放机中，所述装载和卸载设备用于从容纳多个托盘的容纳部分中选择任意盘盒，每个托盘支撑一个盘盒，其中盘形记录介质容纳在盒盒中， 布置在许多上下级中，将所选择的磁盘盒装载到设置在容纳部分后面的记录播放设备中，并且在盘盒的播放之后将其从记录播放设备返回到其在记录播放设备中的原始位置 容纳部具有多个排出操作装置，用于释放盘盒的锁定功能，使得对应于容纳部分中的任意盘盒的操作装置被操作以将盘盒朝向容纳部分的前部排出 。
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