发明授权
- 专利标题： Benzimidazole and pyridylimidazole derivatives
- 专利标题（中）： 苯并咪唑和吡啶基咪唑衍生物
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申请号： US10038069申请日： 2001-12-21
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公开(公告)号： US06916819B2公开(公告)日： 2005-07-12
- 发明人: Guiying Li , John M. Peterson , Pamela Albaugh , Kevin S. Currie , Guolin Cai , Linda M. Gustavson , Kyungae Lee , Alan Hutchison , Vinod Singh , George D. Maynard , Jun Yuan , Ling Hong Xie , Manuka Ghosh , Nian Liu
- 申请人： Guiying Li , John M. Peterson , Pamela Albaugh , Kevin S. Currie , Guolin Cai , Linda M. Gustavson , Kyungae Lee , Alan Hutchison , Vinod Singh , George D. Maynard , Jun Yuan , Ling Hong Xie , Manuka Ghosh , Nian Liu
- 申请人地址： US CT Branford
- 专利权人： Neurogen Corporation
- 当前专利权人： Neurogen Corporation
- 当前专利权人地址： US CT Branford
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; A61K31/4184 ; A61K31/4196 ; A61K31/422 ; A61K31/4245 ; A61K31/435 ; A61K31/437 ; A61K31/438 ; A61K31/4439 ; A61K31/454 ; A61K31/506 ; A61K31/5377 ; A61K31/541 ; A61K31/55 ; A61P25/00 ; A61P25/18 ; A61P25/20 ; A61P25/22 ; A61P25/24 ; A61P25/28 ; C07D233/20 ; C07D233/54 ; C07D401/04 ; C07D401/14 ; C07D403/04 ; C07D403/06 ; C07D403/14 ; C07D405/04 ; C07D405/14 ; C07D409/14 ; C07D413/06 ; C07D413/14 ; C07D417/04 ; C07D417/06 ; C07D417/14 ; C07D471/04 ; C07D473/00 ; C07D491/08 ; C07D491/10 ; C07D491/113 ; C07D403/12
摘要：
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
公开/授权文献
- US20030069257A1 Benzimidazole and pyridylimidazole derivatives 公开/授权日：2003-04-10
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