发明授权
- 专利标题： Methods of modulating pharmacokinetics of oligonucleotides
- 专利标题（中）： 调节寡核苷酸药代动力学的方法
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申请号： US10058740申请日： 2002-01-28
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公开(公告)号： US06921812B1公开(公告)日： 2005-07-26
- 发明人: Thazha P. Prakash , Muthiah Manoharan
- 申请人： Thazha P. Prakash , Muthiah Manoharan
- 申请人地址： US CA Carlsbad
- 专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人： ISIS Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Isis Patent Department Woodcock Washburn LLP
- 主分类号： C07H19/06
- IPC分类号： C07H19/06 ; C12N15/113 ; C07H21/00 ; C07H21/02 ; C07H21/04
摘要：
2′-O-(2-Methylthioethyl), has been incorporated into oligonucleotides and evaluated for antisense properties in comparison with the known 2′-O-(2-methoxyethyl) 2′-O-MOE modification. The 2′-O-MTE modified oligonucleotides exhibit improved binding to human serum albumin compared with the 2′-O-MOE modified oligonucleotides and maintain high binding affinity to target RNA.
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