发明授权
US06933276B1 Methods of treating peripheral neuropathies using neurotrophin-3
失效
使用神经营养因子-3治疗周围神经病变的方法
- 专利标题: Methods of treating peripheral neuropathies using neurotrophin-3
- 专利标题(中): 使用神经营养因子-3治疗周围神经病变的方法
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申请号: US08342457申请日: 1994-11-18
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公开(公告)号: US06933276B1公开(公告)日: 2005-08-23
- 发明人: Andreas Hohn , Yves-Alain Barde , Hans Thoenen , Ronald M. Lindsay , George Yancopoulos
- 申请人: Andreas Hohn , Yves-Alain Barde , Hans Thoenen , Ronald M. Lindsay , George Yancopoulos
- 申请人地址: US NY Tarrytown
- 专利权人: Regeneron Pharmaceuticals, Inc.
- 当前专利权人: Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址: US NY Tarrytown
- 代理商 Valeta Gregg, Esq.
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C07K14/475 ; C07K14/48 ; C07K14/71 ; C07K16/22 ; C07K16/28 ; F02B75/02 ; A61K38/18
摘要:
The present invention relates to neurotrophin-3 (NT-3), a newly discovered member of the BDNF gene family. It is based, in part, on the identification of regions of nucleic acid sequence homology shared by BDNF and NGF (U.S. patent application Ser. No. 07/400,591, filed Aug. 30, 1989, incorporated by reference herein). According to the present invention, these regions of homology may be used to identify new members of the BDNF/NGF gene family; such methodology was used to identify NT-3. The present invention provides for the genes and gene products of new BDNF/NGF related neurotrophic factors identified by these methods. According to the invention, NT-3 may be used in the diagnosis and/or treatment of neurologic disorders, including, but not limited to, Alzheimer's disease and Parkinson's disease. Because NT-3 has been observed to exhibit a spectrum of activity different from the spcificities of BDNF or NGF, NT-3 provides new and valuable options for enducing regrowth and repair in the central nervous system.