发明授权
US06933297B2 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain
失效
7-氯-4-羟基-2-（2-吡啶基乙基）-1,2,5,10-四氢哒嗪并[4,5-b]喹啉-1,10-二酮及其用于治疗疼痛的用途
![7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain](/docs/US/2005-08-23/US06933297B2/abs.jpg.600x600.jpg)
- 专利标题： 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain
- 专利标题（中）： 7-氯-4-羟基-2-（2-吡啶基乙基）-1,2,5,10-四氢哒嗪并[4,5-b]喹啉-1,10-二酮及其用于治疗疼痛的用途
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申请号： US10381922申请日： 2001-09-28
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公开(公告)号： US06933297B2公开(公告)日： 2005-08-23
- 发明人: Dean Gordon Brown , Rebecca Ann Urbanek , Megan Murphy , Wenhua Xiao , Frances Marie McLaren , Edward Vacek , Thomas Bare , Carey Lynn Horchler , Christine Barlaam , Gary Banks Steelman , Vernon Alford
- 申请人： Dean Gordon Brown , Rebecca Ann Urbanek , Megan Murphy , Wenhua Xiao , Frances Marie McLaren , Edward Vacek , Thomas Bare , Carey Lynn Horchler , Christine Barlaam , Gary Banks Steelman , Vernon Alford
- 申请人地址： CH Sodertal
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： CH Sodertal
- 代理商 Kenneth F. Mitchell
- 国际申请： PCT/SE01/02125 WO 20010928
- 国际公布： WO02/26740 WO 20020404
- 主分类号： A61K31/5025
- IPC分类号： A61K31/5025 ; A61P25/04 ; C07D471/04
![7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain](/abs-image/US/2005/08/23/US06933297B2/abs.jpg.150x150.jpg)
摘要：
A compound, 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, its (−) enantiomer, its (+) enantiomer, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administering a pain-ameliorating effective amount of the (−) enantiomer to an individual suffering from pain and pharmaceutical compositions containing the (−) enantiomer are disclosed.
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