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![1, 2, 5, 10-tetrahydropyridazino[4, 5-b]quinoline-1,10-diones and their use for the treatment of pain](/abs-image/US/2004/12/21/US06833368B2/abs.jpg.150x150.jpg)
1.发明授权1, 2, 5, 10-tetrahydropyridazino[4, 5-b]quinoline-1,10-diones and their use for the treatment of pain 失效1,2,5,10-四氢哒嗪并[4,5-b]喹啉-1,10-二酮及其用于治疗疼痛的用途公开(公告)号：US06833368B2
公开(公告)日：2004-12-21
申请号：US10381915
申请日：2003-10-09
申请人： Megan Murphy , Wenhua Xiao , Dean Gordon Brown , Rebecca Ann Urbanek , Frances Marie McLaren , Edward Vacek , Thomas Bare , Carey Lynn Horchler , Christine Barlaam , Gary Banks Steelman , Vernon Alford
发明人： Megan Murphy , Wenhua Xiao , Dean Gordon Brown , Rebecca Ann Urbanek , Frances Marie McLaren , Edward Vacek , Thomas Bare , Carey Lynn Horchler , Christine Barlaam , Gary Banks Steelman , Vernon Alford
IPC分类号： C07D47104
CPC分类号： C07D471/04
摘要： Compounds useful for the treatment of pain in accord with structural diagram (I), or tautomers or pharmaceutically-acceptable salts of such compounds, wherein R1 and A are as disclosed in the specification. Also disclosed are methods for the treatment of pain using compounds according to structural diagram (I) and pharmaceutical compositions comprising compounds according to structural diagram (I).
摘要翻译： 符合结构图（I）或这些化合物的互变异构体或药学上可接受的盐可用于治疗疼痛的化合物，其中R 1和A如说明书中所公开的。 还公开了使用根据结构图（I）的化合物和包含根据结构图（I）的化合物的药物组合物来治疗疼痛的方法。
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![7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain](/abs-image/US/2005/08/23/US06933297B2/abs.jpg.150x150.jpg)
2.发明授权7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain 失效7-氯-4-羟基-2-（2-吡啶基乙基）-1,2,5,10-四氢哒嗪并[4,5-b]喹啉-1,10-二酮及其用于治疗疼痛的用途公开(公告)号：US06933297B2
公开(公告)日：2005-08-23
申请号：US10381922
申请日：2001-09-28
申请人： Dean Gordon Brown , Rebecca Ann Urbanek , Megan Murphy , Wenhua Xiao , Frances Marie McLaren , Edward Vacek , Thomas Bare , Carey Lynn Horchler , Christine Barlaam , Gary Banks Steelman , Vernon Alford
发明人： Dean Gordon Brown , Rebecca Ann Urbanek , Megan Murphy , Wenhua Xiao , Frances Marie McLaren , Edward Vacek , Thomas Bare , Carey Lynn Horchler , Christine Barlaam , Gary Banks Steelman , Vernon Alford
IPC分类号： A61K31/5025 , A61P25/04 , C07D471/04
CPC分类号： C07D471/04
摘要： A compound, 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, its (−) enantiomer, its (+) enantiomer, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administering a pain-ameliorating effective amount of the (−) enantiomer to an individual suffering from pain and pharmaceutical compositions containing the (−) enantiomer are disclosed.
摘要翻译： 化合物7-氯-4-羟基-2-（2-吡啶基乙基）-1,2,5,10-四氢哒嗪并[4,5-b]喹啉-1,10-二酮其（ - ）对映体，其 （+）对映异构体，其药学上可接受的盐，用于治疗疼痛的方法，包括向患有疼痛的个体和（ - ）对映异构体的药物组合物施用改善疼痛的有效量的（ - ）对映异构体。
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![1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain](/abs-image/US/2005/09/20/US06946463B2/abs.jpg.150x150.jpg)
3.发明授权1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain 失效1,2,5,10-四氢哒嗪[4,5-b]喹啉-1,10-二酮及其用于治疗疼痛的用途公开(公告)号：US06946463B2
公开(公告)日：2005-09-20
申请号：US10381921
申请日：2001-09-28
申请人： Dean Gordon Brown , Rebecca Ann Urbanek , Megan Murphy , Wenhua Xiao , Frances Marie McLaren , Edward Vacek , Thomas Bare , Carey Lynn Horchler , Christine Barlaam , Gary Banks Steelman
发明人： Dean Gordon Brown , Rebecca Ann Urbanek , Megan Murphy , Wenhua Xiao , Frances Marie McLaren , Edward Vacek , Thomas Bare , Carey Lynn Horchler , Christine Barlaam , Gary Banks Steelman
IPC分类号： A61K31/444 , A61P25/04 , A61P43/00 , C07D471/04 , A61K31/5025
CPC分类号： C07D471/04
摘要： Compounds according to structural diagram (I) are disclosed, wherein R1, A, E and D are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram (I). The following is an examiner's statement of reasons for allowance: In view of applicants' amendments to the claims which limit “E” to phenyl or cycloalkyl groups the rejections of the previous action no longer pertain as they at best teach “E” as alkyl.
摘要翻译： 公开了根据结构图（I）的化合物，其中R 1，A，E和D如说明书中所定义。 还公开了根据结构图（I）包含疼痛改善有效量的化合物的药物组合物。 以下是审查员关于津贴原因的说明：鉴于申请人对“E”对苯基或环烷基的限制的修正案，以前的行为的拒绝不再属于“E”为烷基。
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公开(公告)号：US06730675B2
公开(公告)日：2004-05-04
申请号：US10168762
申请日：2003-02-12
申请人： Megan Murphy , Rebecca Ann Urbanek , Wenhua Xiao , Gary Banks Steelman , Dean Gordon Brown , Thomas Michael Bare
发明人： Megan Murphy , Rebecca Ann Urbanek , Wenhua Xiao , Gary Banks Steelman , Dean Gordon Brown , Thomas Michael Bare
IPC分类号： C07D47104
CPC分类号： C07D471/04 , A61K31/5025 , A61K31/503 , A61K31/5377 , A61K31/541 , C07D487/04
摘要： Compounds according to structural diagram I are disclosed; wherein R1, A and D are as defined in the specification. Also disclosed are methods for treating pain comprising administration of a pain-ameliorating effective amount of a compound in accord with structural diagram I and pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram I.
摘要翻译： 公开了根据结构图I的化合物;其中R 1，A和D如说明书中所定义。 还公开了治疗疼痛的方法，其包括根据结构图I施用改善疼痛的有效量的化合物，以及根据结构图I包含疼痛改善的有效量的化合物的药物组合物。
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公开(公告)号：US06943165B2
公开(公告)日：2005-09-13
申请号：US10934753
申请日：2004-09-03
IPC分类号： A61K31/502 , A61K31/5025 , A61K31/503 , A61K31/5377 , A61K31/541 , C07D471/04 , C07D487/04 , A61K31/495 , A01N43/58 , A01N43/60 , A61K31/50 , C07D237/26
CPC分类号： C07D471/04 , A61K31/502 , A61K31/5025 , A61K31/503 , A61K31/5377 , A61K31/541 , C07D487/04
摘要： A compound, 7-chloro-4-hydroxy-2-(2-chloro-4-methylphenyl)-1,2,5,10-tetrahydropyridazino [4,5-b]quinoline-1,10-dione, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administration of a pain-ameliorating effective amount of the compound and pharmaceutical compositions containing the compound.
摘要翻译： 化合物7-氯-4-羟基-2-（2-氯-4-甲基苯基）-1,2,5,10-四氢哒嗪并[4,5-b]喹啉-1,10-二酮，药学上可接受的 其盐，治疗疼痛的方法，包括施用改善疼痛的有效量的化合物和含有该化合物的药物组合物。
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公开(公告)号：US06787547B2
公开(公告)日：2004-09-07
申请号：US10168760
申请日：2003-01-21
IPC分类号： C07D47104
CPC分类号： C07D471/04 , A61K31/502 , A61K31/5025 , A61K31/503 , A61K31/5377 , A61K31/541 , C07D487/04
摘要： A compound, 7-chloro-4-hydroxy-2-(2-chloro-4-methylphenyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administration of a pain-ameliorating effective amount of the compound and pharmaceutical compositions containing the compound.
摘要翻译： 化合物7-氯-4-羟基-2-（2-氯-4-甲基苯基）-1,2,5,10-四氢哒嗪并[4,5-b]喹啉-1,10-二酮，药学上可接受的 其盐，治疗疼痛的方法，包括施用改善疼痛的有效量的化合物和含有该化合物的药物组合物。
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