发明授权
- 专利标题： Nucleic acids encoding costimulatory molecule B7-4
- 专利标题（中）： 编码共刺激分子B7-4的核酸
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申请号： US09644934申请日： 2000-08-23
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公开(公告)号： US06936704B1公开(公告)日： 2005-08-30
- 发明人: Gordon Freeman , Vassiliki Boussiotis , Tatyana Chernova , Nelly Malenkovich
- 申请人： Gordon Freeman , Vassiliki Boussiotis , Tatyana Chernova , Nelly Malenkovich
- 申请人地址： US MA Boston
- 专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人： Dana-Farber Cancer Institute, Inc.
- 当前专利权人地址： US MA Boston
- 代理机构： Lahive & Cockfield, LLP
- 代理商 Amy E. Mandragouras, Esq.; Megan E. Williams, Esq.
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61K38/00 ; A61K39/00 ; A61K39/395 ; A61K45/06 ; A61P35/00 ; A61P37/02 ; C07K14/705 ; C07K16/28 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N15/09 ; C12N15/12 ; C12P21/02 ; G01N33/15 ; G01N33/53 ; C07H21/04 ; C12N15/63 ; C12N15/87
摘要：
The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-4 gene has been introduced or disrupted. The invention still further provides isolated B7-4 proteins, fusion proteins, antigenic peptides and anti-B7-4 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
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