发明授权
- 专利标题： Compound containing a labile disulfide bond
- 专利标题（中）： 含有不稳定二硫键的化合物
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申请号： US09795607申请日： 2001-02-28
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公开(公告)号： US06936729B2公开(公告)日： 2005-08-30
- 发明人: Jon A. Wolff , Sean D. Monahan , Vladimir G. Budker , Paul M. Slattum , David B. Rozema
- 申请人： Jon A. Wolff , Sean D. Monahan , Vladimir G. Budker , Paul M. Slattum , David B. Rozema
- 申请人地址： US WI Madison
- 专利权人： Mirus Bio Corporation
- 当前专利权人： Mirus Bio Corporation
- 当前专利权人地址： US WI Madison
- 代理商 Mark K. Johnson; Kirk Ekena
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07C323/60 ; C07C323/62 ; C07D207/46 ; C11D1/60 ; A61K9/127 ; C12N15/88
摘要：
A labile disulfide-containing compound under physiological conditions, comprising: the disulfide-containing compound having a labile disulfide bond that is either a disulfide bond that is cleaved more rapidly than oxidized glutathione or a disulfide bond constructed from thiols in which one of the constituent thiols has a lower pKa than glutathione or a disulfide bond that is activated by intramolecular attack from a free thiol.
公开/授权文献
- US20010036926A1 Compound containing a labile disulfide bond 公开/授权日：2001-11-01
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