发明授权
US06943149B2 Benzimidazolone peptidomimetics as thrombin receptor antagonists
有权
苯并咪唑酮肽模拟物作为凝血酶受体拮抗剂
- 专利标题： Benzimidazolone peptidomimetics as thrombin receptor antagonists
- 专利标题（中）： 苯并咪唑酮肽模拟物作为凝血酶受体拮抗剂
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申请号： US10390098申请日： 2003-03-17
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公开(公告)号： US06943149B2公开(公告)日： 2005-09-13
- 发明人: Han-Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly B. White
- 申请人： Han-Cheng Zhang , Bruce E. Maryanoff , David F. McComsey , Kimberly B. White
- 申请人地址： US NJ Raritan US MA Cambridge
- 专利权人： Ortho McNeil Pharmaceutical, Inc.,Millennium Pharmaceuticals, Inc.
- 当前专利权人： Ortho McNeil Pharmaceutical, Inc.,Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US NJ Raritan US MA Cambridge
- 代理商 Gabriel Lopez; Hal Woodrow
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07D235/26 ; C07K5/06 ; G01R1/067 ; G01R1/073 ; G01R3/00 ; H05K3/40
摘要：
The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
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