- 专利标题: Stabilized preparations for use in nebulizers
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申请号: US09218213申请日: 1998-12-22
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公开(公告)号: US06946117B1公开(公告)日: 2005-09-20
- 发明人: Ernest G. Schutt , Thomas E. Tarara , Luis A. Dellamary , Alexey Kabalnov , Jeffry G. Weers
- 申请人: Ernest G. Schutt , Thomas E. Tarara , Luis A. Dellamary , Alexey Kabalnov , Jeffry G. Weers
- 申请人地址: US CA San Carlos
- 专利权人: Nektar Therapeutics
- 当前专利权人: Nektar Therapeutics
- 当前专利权人地址: US CA San Carlos
- 代理商 Guy V. Tucker
- 主分类号: A61F2/00
- IPC分类号: A61F2/00 ; A61F13/00 ; A61K9/00 ; A61K9/14 ; A61K9/16 ; A61L9/04 ; A61M11/00
摘要:
Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a stabilized colloidal system which may comprise a fluorochemical component. In particularly preferred embodiments, the stabilized dispersions comprise perforated microstructures dispersed in a fluorochemical suspension medium. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a nebulizer.
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