发明授权
US06957150B2 Methods for identifying an agent that interacts with an active site of acyl carrier protein synthase or acyl carrier protein synthase complex
失效
用于鉴定与酰基载体蛋白质合成酶或酰基载体蛋白质合酶复合物的活性位点相互作用的试剂的方法
- 专利标题： Methods for identifying an agent that interacts with an active site of acyl carrier protein synthase or acyl carrier protein synthase complex
- 专利标题（中）： 用于鉴定与酰基载体蛋白质合成酶或酰基载体蛋白质合酶复合物的活性位点相互作用的试剂的方法
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申请号： US09771383申请日： 2001-01-25
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公开(公告)号： US06957150B2公开(公告)日： 2005-10-18
- 发明人: Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl
- 申请人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl
- 申请人地址： US NJ Madison US MA Cambridge
- 专利权人： Wyeth,Millennium Pharmaceuticals, Inc.
- 当前专利权人： Wyeth,Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US NJ Madison US MA Cambridge
- 代理机构： Fish & Richardson P.C.
- 主分类号： C12N9/12
- IPC分类号： C12N9/12 ; G06F19/00 ; G01N31/00 ; G01N33/48
摘要：
This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.