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1.发明授权Methods for identifying an agent that interacts with an active site of acyl carrier protein synthase or acyl carrier protein synthase complex 失效用于鉴定与酰基载体蛋白质合成酶或酰基载体蛋白质合酶复合物的活性位点相互作用的试剂的方法公开(公告)号：US06957150B2
公开(公告)日：2005-10-18
申请号：US09771383
申请日：2001-01-25
申请人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl
发明人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl
CPC分类号： C12N9/1288
摘要： This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.
摘要翻译： 本发明涉及酰基载体蛋白合成酶（ACPS）晶体和酰基载体蛋白合成酶辅酶A（ACPS-CoA）复合物的晶体，以及这些晶体的用途来确定ACPS的三维结构。 本发明进一步涉及使用合理的药物设计方法来鉴定可与ACPS和ACPS-CoA复合物的活性位点相互作用的试剂，以及这些试剂的测试以鉴定可抑制ACPS和/或ACPS-CoA的药剂 复杂的活动。
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2.发明授权Method for identifying or designing a candidate agent that interacts with LINGO-1 polypeptide using a LINGO-1 three-dimensional structure 失效使用LINGO-1三维结构识别或设计与LINGO-1多肽相互作用的候选试剂的方法公开(公告)号：US07693698B2
公开(公告)日：2010-04-06
申请号：US11701635
申请日：2007-02-01
申请人： Lidia Mosyak , Brian Dwyer , Mark Johnson , Xiaotian Zhong , Eleonora Presman , James M. Wilhelm , Mark Stahl , William Stuart Somers
发明人： Lidia Mosyak , Brian Dwyer , Mark Johnson , Xiaotian Zhong , Eleonora Presman , James M. Wilhelm , Mark Stahl , William Stuart Somers
CPC分类号： C07K14/4703 , C07K14/705 , C07K2299/00
摘要： This disclosure relates to LINGO-1 polypeptides, LINGO-1 polypeptide/ligand complexes, crystals of LINGO-1 polypeptides, crystals of LINGO-1 polypeptide/ligand complexes, and related methods and software systems.
摘要翻译： 本公开涉及LINGO-1多肽，LINGO-1多肽/配体复合物，LINGO-1多肽的晶体，LINGO-1多肽/配体复合物的晶体，以及相关方法和软件系统。
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3.发明授权公开(公告)号：US07135319B2
公开(公告)日：2006-11-14
申请号：US10717138
申请日：2003-11-19
申请人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl
发明人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl
IPC分类号： C12N9/10
CPC分类号： C12N9/1288 , G06F19/16
摘要： This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.
摘要翻译： 本发明涉及与酰基载体蛋白（ACP）络合的酰基载体蛋白质合成酶（ACPS），枯草芽孢杆菌ACP的溶液结构的晶体结构，以及在合理的药物设计方法中使用这些结构来鉴定 可能与ACPS和ACP的活性位点相互作用，以及这些试剂的测试以鉴定可能代表新型抗生素的药剂。
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公开(公告)号：US07584087B2
公开(公告)日：2009-09-01
申请号：US11099958
申请日：2005-04-06
申请人： Zhang Bao Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Stuart Somers , Lidia Mosyak
发明人： Zhang Bao Xu , Stephane Olland , Scott Wolfrom , Karl Malakian , Laura Lin , Mark Stahl , Julie Lee , Lori Fitz , Rita Greco , Divya Chaudhary , William Stuart Somers , Lidia Mosyak
CPC分类号： C12N9/1205 , C07K2299/00 , C12Q1/485 , G01N33/564 , G01N33/57426 , G01N2500/04
摘要： A three-dimensional structure of human protein kinase C theta (PKCθ) can be used in methods of designing an agent that interacts with PKCθ. The agent can be an inhibitor of PKCθ activity.
摘要翻译： 人蛋白激酶Cθ（PKCθ）的三维结构可用于设计与PKCθ相互作用的试剂的方法中。 该药物可以是PKCθ活性的抑制剂。
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公开(公告)号：US07555415B2
公开(公告)日：2009-06-30
申请号：US11334982
申请日：2006-01-18
申请人： Lidia Mosyak , Zhang Bao Xu , Mark Stahl , Wah-Tung Hum , William Stuart Somers , Eric Steven Manas
发明人： Lidia Mosyak , Zhang Bao Xu , Mark Stahl , Wah-Tung Hum , William Stuart Somers , Eric Steven Manas
CPC分类号： C07K14/721 , C07K2299/00
摘要： Estrogen receptor ligands, estrogen receptor polypeptide/ligand complexes, crystals of estrogen receptor polypeptide/ligand complexes, and related methods and software systems are disclosed.
摘要翻译： 雌激素受体配体，雌激素受体多肽/配体配合物，雌激素受体多肽/配体复合物的晶体以及相关方法和软件系统。
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6.发明授权Methods for identifying agents that interact with an active site of acyl carrier protein synthase-acyl carrier protein complex 失效用于鉴定与酰基载体蛋白合酶 - 酰基载体蛋白复合物的活性位点相互作用的试剂的方法公开(公告)号：US06684162B2
公开(公告)日：2004-01-27
申请号：US09770834
申请日：2001-01-25
申请人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl , Robert Powers , Guang-Yi Xu
发明人： Kevin Delos Parris , William Stuart Somers , Amy Szepui Tam , Laura Long Lin , Mark Lloyd Stahl , Robert Powers , Guang-Yi Xu
IPC分类号： G06F1900
CPC分类号： C12N9/1288 , G06F19/16
摘要： This invention is directed to the crystal structure of Acyl Carrier Protein Synthase (ACPS) complexed with Acyl Carrier Protein (ACP), the solution structure of B. subtilis ACP, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of ACPS and ACP, and to the testing of these agents to identify agents that may represent novel antibiotics.
摘要翻译： 本发明涉及与酰基载体蛋白（ACP）络合的酰基载体蛋白质合成酶（ACPS），枯草芽孢杆菌ACP的溶液结构的晶体结构，以及在合理的药物设计方法中使用这些结构来鉴定 可能与ACPS和ACP的活性位点相互作用，以及这些试剂的测试以鉴定可能代表新型抗生素的药剂。
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