A multipoint lock system for use with the active and inactive doors of two-door sets, which provides an operator with the ability to lock or unlock a plurality of locking points both manually and automatically, and features a blocking mechanism to prevent unwanted locking. The system comprises a pair of releasably engaged mechanisms, one of which primarily controls the deployment of the locking members, while the other primarily controls the receiving windows that receive the locking members. Each mechanism is operated by a lever and thumbturn attached to a centralized cassette.