A distributed refrigeration system for a vehicle includes a vapor compression primary cooling circuit and a separate secondary cooling circuit. The secondary cooling circuit utilizes a non-toxic cooling fluid that is pumped to remote locations in the vehicle through designated supply lines. A heat exchanger acting with the primary cooling circuit cools the cooling fluid. A portable main storage compartment is fluidly connectable to the primary or secondary cooling circuits. The portable main cold storage compartment can be expandable. At the remote locations in the vehicle, docking stations permit items to be selectively cooled by the secondary cooling circuit. Both the primary and secondary cooling circuits can operate independently of the vehicle engine.