发明授权
US06977249B1 Process for producing an iron-dextran compound, iron-dextran compound produced according to said process, pharmaceutical composition for prophylaxis or treatment of iron-deficiency and use of said compound for the preparation of parenterally administrable pharmaceutical composition
失效
用于制备铁 - 葡聚糖化合物的方法，根据所述方法制备的铁 - 葡聚糖化合物，用于预防或治疗缺铁的药物组合物和所述化合物用于制备肠胃外给药的药物组合物
- 专利标题： Process for producing an iron-dextran compound, iron-dextran compound produced according to said process, pharmaceutical composition for prophylaxis or treatment of iron-deficiency and use of said compound for the preparation of parenterally administrable pharmaceutical composition
- 专利标题（中）： 用于制备铁 - 葡聚糖化合物的方法，根据所述方法制备的铁 - 葡聚糖化合物，用于预防或治疗缺铁的药物组合物和所述化合物用于制备肠胃外给药的药物组合物
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申请号： US09509681申请日： 1999-07-29
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公开(公告)号： US06977249B1公开(公告)日： 2005-12-20
- 发明人: Hans Berg Andreasen , Lars Christensen
- 申请人： Hans Berg Andreasen , Lars Christensen
- 申请人地址： DE Rosklide
- 专利权人： Pharmacosmos Holding A/S
- 当前专利权人： Pharmacosmos Holding A/S
- 当前专利权人地址： DE Rosklide
- 代理机构： Sughrue Mion, PLLC
- 优先权： DK199801526 19981120
- 国际申请： PCT/DK99/00425 WO 19990729
- 国际公布： WO00/30657 WO 20000602
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K9/08 ; A61K31/295 ; A61K31/715 ; A61K31/721 ; A61K47/12 ; A61K47/48 ; A61P3/02 ; A61P7/06 ; C08B37/00 ; C08B37/02 ; A61K31/70
摘要：
In a process for producing an iron-dextran compound for use in parenteral treatment of iron-deficiency in humans or animals a stable compound of desired relatively low molecular weight is obtained by using first hydrogenation and then oxidation to convert reducing terminal groups on the dextran molecules before reaction with the iron. By varying the ratio of hydrogenated groups to oxygenated groups the average molecular weight of the resulting iron-dextran compound can be varied.
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