Invention Grant
US06979431B2 Method for labelling technetium or rhenium using borohydride exchange resin
失效
使用硼氢化物交换树脂标记锝或铼的方法
- Patent Title: Method for labelling technetium or rhenium using borohydride exchange resin
- Patent Title (中): 使用硼氢化物交换树脂标记锝或铼的方法
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Application No.: US10253515Application Date: 2002-09-24
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Publication No.: US06979431B2Publication Date: 2005-12-27
- Inventor: Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
- Applicant: Kyung Bae Park , Sang Hyun Park , Hui Jeong Gwon , Sun Ju Choi , Byung Chul Shin , Young Don Hong , Sang Mu Choi , Woong Woo Park , Kwang Hee Han , Beom Su Jang
- Applicant Address: KR Daejeon
- Assignee: Korea Atomic Energy Research Institute
- Current Assignee: Korea Atomic Energy Research Institute
- Current Assignee Address: KR Daejeon
- Agency: Bachman & LaPointe, P.C.
- Priority: KR2002-20298 20020415
- Main IPC: C01B17/20
- IPC: C01B17/20 ; C07F13/00 ; A61K51/00 ; C01G47/00 ; C01G57/00
Abstract:
A method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin to obtain a complex of technetium or rhenium with the sulfide compound. The method can directly label disulfide compounds with technetium or rhenium, can skip the synthetic step of thiol-protected S-precursor, and is useful for high value-added radiopharmaceuticals.
Public/Granted literature
- US20030194365A1 Method for labelling technetium or rhenium using borohydride exchange resin Public/Granted day:2003-10-16
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