- 专利标题: Substituted 2-azetidinones useful as hypocholesterolemic agents
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申请号: US10166942申请日: 2002-06-11
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公开(公告)号: US06982251B2公开(公告)日: 2006-01-03
- 发明人: Anima Ghosal , Shmuel Zbaida , Swapan K. Chowdhury , Robert M. Iannucci , Wenqing Feng , Kevin B. Alton , James E. Patrick , Harry R. Davis
- 申请人: Anima Ghosal , Shmuel Zbaida , Swapan K. Chowdhury , Robert M. Iannucci , Wenqing Feng , Kevin B. Alton , James E. Patrick , Harry R. Davis
- 申请人地址: US NJ Kenilworth
- 专利权人: Schering Corporation
- 当前专利权人: Schering Corporation
- 当前专利权人地址: US NJ Kenilworth
- 代理商 Richard A. Elder
- 主分类号: A61K31/7056
- IPC分类号: A61K31/7056 ; A61K31/397 ; A61K31/675 ; C07H17/02 ; C07D25/08
摘要:
Hypocholesterolemic substituted 2-azetidinone compounds of the formula: are disclosed, as well as a methods of lowering cholesterol by administering said compounds, pharmaceutical compositions containing them, and the combination of a substituted 2-azetidinone cholesterol-lowering agent and a cholesterol biosynthesis inhibitor for the treatment and prevention of atherosclerosis.