Invention Grant
US06984645B2 Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
有权
脂肪细胞脂肪酸结合蛋白和角质形成细胞脂肪酸结合蛋白的双重抑制剂
- Patent Title: Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
- Patent Title (中): 脂肪细胞脂肪酸结合蛋白和角质形成细胞脂肪酸结合蛋白的双重抑制剂
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Application No.: US10295819Application Date: 2002-11-15
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Publication No.: US06984645B2Publication Date: 2006-01-10
- Inventor: David R. Magnin , Richard B. Sulsky , Jeffrey A. Robl , Thomas J. Caulfield , Rex A. Parker
- Applicant: David R. Magnin , Richard B. Sulsky , Jeffrey A. Robl , Thomas J. Caulfield , Rex A. Parker
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Joseph C. Wang; Laurelee A. Duncan
- Main IPC: A61K31/435
- IPC: A61K31/435 ; A61K31/19 ; A61K31/195 ; C07D233/54 ; C07D65/03
Abstract:
Compounds that are dual aP2/k-FABP inhibitors are provided having the formula wherein A, B, X, Y, R1, R2 and R3 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin, glyburide, troglitazone and/or insulin.
Public/Granted literature
- US20030225091A1 Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein Public/Granted day:2003-12-04
Information query
