发明授权
- 专利标题： Matrix metalloproteinase inhibitors
- 专利标题（中）： 基质金属蛋白酶抑制剂
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申请号： US09783248申请日： 2001-02-14
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公开(公告)号： US06989139B2公开(公告)日： 2006-01-24
- 发明人: Carl P. Decicco , David J. Nelson , John A. Barrett , Alan P. Carpenter Jr. , Jingwu Duan , Milind Rajopadhye
- 申请人： Carl P. Decicco , David J. Nelson , John A. Barrett , Alan P. Carpenter Jr. , Jingwu Duan , Milind Rajopadhye
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人地址： US NJ Princeton
- 代理机构： Woodcock Washburn LLP
- 代理商 Warren E. Volles
- 主分类号： A61K31/395
- IPC分类号： A61K31/395 ; C07D267/00 ; C07D401/12 ; C07D413/12 ; C07F9/6527
摘要：
Thus the present invention describes novel compounds comprising 1-10 targeting moieties; a chelator (Ch); and 0-1 linking groups (Ln) between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to a cytotoxic radioisotope. The present invention also provides novel compositions of the compounds of the invention, kits and their uses in treatment of diseases associated with MMPs.
公开/授权文献
- US20050025702A1 MATRIX METALLOPROTEINASE INHIBITORS 公开/授权日：2005-02-03
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