Invention Grant
- Patent Title: Matrix metalloproteinase inhibitors
- Patent Title (中): 基质金属蛋白酶抑制剂
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Application No.: US09783248Application Date: 2001-02-14
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Publication No.: US06989139B2Publication Date: 2006-01-24
- Inventor: Carl P. Decicco , David J. Nelson , John A. Barrett , Alan P. Carpenter Jr. , Jingwu Duan , Milind Rajopadhye
- Applicant: Carl P. Decicco , David J. Nelson , John A. Barrett , Alan P. Carpenter Jr. , Jingwu Duan , Milind Rajopadhye
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Pharma Company
- Current Assignee: Bristol-Myers Squibb Pharma Company
- Current Assignee Address: US NJ Princeton
- Agency: Woodcock Washburn LLP
- Agent Warren E. Volles
- Main IPC: A61K31/395
- IPC: A61K31/395 ; C07D267/00 ; C07D401/12 ; C07D413/12 ; C07F9/6527
Abstract:
Thus the present invention describes novel compounds comprising 1-10 targeting moieties; a chelator (Ch); and 0-1 linking groups (Ln) between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to a cytotoxic radioisotope. The present invention also provides novel compositions of the compounds of the invention, kits and their uses in treatment of diseases associated with MMPs.
Public/Granted literature
- US20050025702A1 MATRIX METALLOPROTEINASE INHIBITORS Public/Granted day:2005-02-03
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