发明授权
US06989244B1 Method for screening compounds inhibiting signal transduction through inflammatory cytokines
失效
筛选通过炎性细胞因子抑制信号转导的化合物的方法
- 专利标题： Method for screening compounds inhibiting signal transduction through inflammatory cytokines
- 专利标题（中）： 筛选通过炎性细胞因子抑制信号转导的化合物的方法
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申请号： US09830144申请日： 1999-10-21
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公开(公告)号： US06989244B1公开(公告)日： 2006-01-24
- 发明人: Masayuki Tsuchiya , Toshihiko Ohtomo , Yasuhiro Sugamata , Kunihiro Matsumoto
- 申请人： Masayuki Tsuchiya , Toshihiko Ohtomo , Yasuhiro Sugamata , Kunihiro Matsumoto
- 申请人地址： JP Tokyo
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo
- 代理机构： Fish & Richardson P.C.
- 优先权： JP10-299962 19981021
- 国际申请： PCT/JP99/05817 WO 19991021
- 国际公布： WO00/23610 WO 20000427
- 主分类号： C12Q1/48
- IPC分类号： C12Q1/48 ; C07K1/00 ; C07H21/04 ; G01N33/53
摘要：
The present invention relates to methods of screening for compounds that inhibit signal transduction by inflammatory cytokines. The methods include providing a sample that contains a TAK1 and a TAB1; contacting the sample with a compound; detecting binding between the TAK1 and the TAB1; and selecting the compound if binding between the TAK1 and TAB1 is inhibited in the sample compared to a control.
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