Invention Grant
- Patent Title: Benzamide derivatives, processes for their preparation, and their pharmaceutical use
- Patent Title (中): 苯甲酰胺衍生物，其制备方法及其药物用途
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Application No.: US10496269Application Date: 2002-11-29
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Publication No.: US06992103B2Publication Date: 2006-01-31
- Inventor: Andrew Faller , David Timothy MacPherson , Peter Henry Milner , Steven James Stanway , Leontine Saskia Trouw
- Applicant: Andrew Faller , David Timothy MacPherson , Peter Henry Milner , Steven James Stanway , Leontine Saskia Trouw
- Applicant Address: GB Brentford
- Assignee: SmithKline Beecham P.L.C.
- Current Assignee: SmithKline Beecham P.L.C.
- Current Assignee Address: GB Brentford
- Agent Bonnie L. Deppenbrock
- Priority: GB0128748 20011130; GB0214090 20020618
- International Application: PCT/EP02/13515 WO 20021129
- International Announcement: WO03/045913 WO 20030605
- Main IPC: A61K31/4015
- IPC: A61K31/4015 ; A61K31/4166 ; A61K31/4439 ; C07D207/24 ; C07D223/10
Abstract:
The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.
Public/Granted literature
- US20050085520A1 Benzamide derivatives, processes for their preparation, and their pharmaceutical use Public/Granted day:2005-04-21
Information query
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