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公开(公告)号:US20120172378A1
公开(公告)日:2012-07-05
申请号:US13309941
申请日:2011-12-02
申请人: Deirdre Mary Bernadette HICKEY , Robert John Ife , Colin Andrew Leach , Ivan Leo Pinto , Stephen Allan Smith , Steven James Stanway
发明人: Deirdre Mary Bernadette HICKEY , Robert John Ife , Colin Andrew Leach , Ivan Leo Pinto , Stephen Allan Smith , Steven James Stanway
IPC分类号: A61K31/517 , C07D239/70 , A61P9/10 , C07D401/12 , C07D239/56 , A61K31/513 , C07D403/12
CPC分类号: C07D239/56 , C07D239/60 , C07D239/70 , C07D239/95 , C07D401/12 , C07D403/12 , C07D495/04
摘要: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
摘要翻译: 式(I)的嘧啶酮化合物:是Lp-PLA2酶的抑制剂,可用于治疗动脉粥样硬化。
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2.
公开(公告)号:US20100087502A1
公开(公告)日:2010-04-08
申请号:US12529561
申请日:2008-03-05
申请人: Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy Macpherson , Aaron B. Miller , Antoinette Naylor , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani
发明人: Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy Macpherson , Aaron B. Miller , Antoinette Naylor , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani
IPC分类号: A61K31/416 , C07D231/56 , A61P9/00 , A61P25/00 , A61P29/00 , A61P37/00 , A61P3/00
CPC分类号: C07D231/56
摘要: The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译: 本发明涉及具有药理学活性的新的吲唑衍生物,其制备方法,含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。
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公开(公告)号:US08536182B2
公开(公告)日:2013-09-17
申请号:US11996650
申请日:2006-07-24
申请人: Christopher Norbert Johnson , David Timothy Macpherson , Steven James Stanway , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
发明人: Christopher Norbert Johnson , David Timothy Macpherson , Steven James Stanway , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
IPC分类号: A61K31/497 , A61K31/44 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00
CPC分类号: C07D401/10 , C07D401/14
摘要: The present invention relates to novel benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
摘要翻译: 本发明涉及新型苄基哌嗪衍生物,例如具有作为GPR38受体激动剂的活性的式(I)化合物,以及这些化合物或其药物组合物在治疗胃肠道疾病中的用途。
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公开(公告)号:US07956083B2
公开(公告)日:2011-06-07
申请号:US12864933
申请日:2009-02-17
申请人: Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
发明人: Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
IPC分类号: A01N43/38 , C07D209/04
CPC分类号: C07D209/08
摘要: The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译: 本发明涉及具有药理活性的新型吲哚衍生物,其制备方法,含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。
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公开(公告)号:US07638520B2
公开(公告)日:2009-12-29
申请号:US11561926
申请日:2006-11-21
申请人: Deirdre Mary Bernadette Hickey , Robert John Ife , Colin Andrew Leach , Ivan Leo Pinto , Stephen Allan Smith , Steven James Stanway
发明人: Deirdre Mary Bernadette Hickey , Robert John Ife , Colin Andrew Leach , Ivan Leo Pinto , Stephen Allan Smith , Steven James Stanway
IPC分类号: C07D239/70 , A61K31/517
CPC分类号: C07D239/56 , C07D239/60 , C07D239/70 , C07D239/95 , C07D401/12 , C07D403/12 , C07D495/04
摘要: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
摘要翻译: 式(I)的嘧啶酮化合物:是Lp-PLA2酶的抑制剂,可用于治疗动脉粥样硬化。
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公开(公告)号:US20090170877A1
公开(公告)日:2009-07-02
申请号:US12372837
申请日:2009-02-18
申请人: Deirdre Mary Bernadette Hickey , Robert John Ife , Colin Andrew Leach , Ivan Leo Pinto , Stephen Allan Smith , Steven James Stanway
发明人: Deirdre Mary Bernadette Hickey , Robert John Ife , Colin Andrew Leach , Ivan Leo Pinto , Stephen Allan Smith , Steven James Stanway
IPC分类号: A61K31/506 , A61K31/517 , A61K31/513 , A61P29/00 , A61P25/00 , A61P25/28
CPC分类号: C07D239/56 , C07D239/60 , C07D239/70 , C07D239/95 , C07D401/12 , C07D403/12 , C07D495/04
摘要: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
摘要翻译: 式(I)的嘧啶酮化合物:是Lp-PLA2酶的抑制剂,可用于治疗动脉粥样硬化。
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7.
公开(公告)号:US06441167B1
公开(公告)日:2002-08-27
申请号:US09720172
申请日:2001-02-16
IPC分类号: C07D23726
CPC分类号: C07D491/04 , C07C229/16 , C07C229/76 , C07C233/83 , G01N33/582
摘要: This invention relates to novel compounds that can complex with lanthanide cations, processes for their preparation and the use of the resulting lanthanide chelates as biomolecular probes.
摘要翻译: 本发明涉及可与镧系元素阳离子络合的新化合物,其制备方法和所得镧系螯合物用作生物分子探针。
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公开(公告)号:US08871775B2
公开(公告)日:2014-10-28
申请号:US13309941
申请日:2011-12-02
申请人: Deirdre Mary Bernadette Hickey , Robert John Ife , Colin Andrew Leach , Ivan Leo Pinto , Stephen Allan Smith , Steven James Stanway
发明人: Deirdre Mary Bernadette Hickey , Robert John Ife , Colin Andrew Leach , Ivan Leo Pinto , Stephen Allan Smith , Steven James Stanway
IPC分类号: A61K31/519 , C07D473/00 , C07D239/02 , C07D239/95 , C07D239/56 , C07D239/60 , C07D403/12 , C07D495/04 , C07D239/70 , C07D401/12
CPC分类号: C07D239/56 , C07D239/60 , C07D239/70 , C07D239/95 , C07D401/12 , C07D403/12 , C07D495/04
摘要: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
摘要翻译: 式(I)的嘧啶酮化合物:是Lp-PLA2酶的抑制剂,可用于治疗动脉粥样硬化。
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公开(公告)号:US20090118313A1
公开(公告)日:2009-05-07
申请号:US12349086
申请日:2009-01-06
申请人: Deirdre Mary Bernadette Hickey , Robert John Ife , Colin Andrew Leach , Ivan Leo Pinto , Stephen Allan Smith , Steven James Stanway
发明人: Deirdre Mary Bernadette Hickey , Robert John Ife , Colin Andrew Leach , Ivan Leo Pinto , Stephen Allan Smith , Steven James Stanway
IPC分类号: A61K31/519 , A61K31/506 , A61K31/513 , A61P9/10 , A61K31/505 , A61K31/517
CPC分类号: C07D239/56 , C07D239/60 , C07D239/70 , C07D239/95 , C07D401/12 , C07D403/12 , C07D495/04
摘要: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
摘要翻译: 式(I)的嘧啶酮化合物:是Lp-PLA2酶的抑制剂,可用于治疗动脉粥样硬化。
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公开(公告)号:US07470694B2
公开(公告)日:2008-12-30
申请号:US11561035
申请日:2006-11-17
IPC分类号: A61K31/517
CPC分类号: C07D239/56 , C07D239/60 , C07D239/70 , C07D239/95 , C07D401/12 , C07D403/12 , C07D495/04
摘要: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
摘要翻译: 式(I)的嘧啶酮化合物:是Lp-PLA2酶的抑制剂,可用于治疗动脉粥样硬化。
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