发明授权
- 专利标题： Indolyl and dihydroindolyl derivatives, their manufacture and use as pharmaceutical agents
- 专利标题（中）： 吲哚基和二氢吲哚衍生物，其制备和用作药剂
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申请号： US10978144申请日： 2004-10-29
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公开(公告)号： US06995263B2公开(公告)日： 2006-02-07
- 发明人: Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
- 申请人： Jean Ackermann , Johannes Aebi , Alfred Binggeli , Uwe Grether , Georges Hirth , Bernd Kuhn , Hans-Peter Maerki , Markus Meyer , Peter Mohr , Matthew Blake Wright
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni
- 优先权： EP03104083 20031105
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D401/14 ; C07D403/02
摘要：
This invention relates to compounds of the formula wherein one of R6, R7 and R8 is and X, Y1 to Y4, R1 to R14 and n are as defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
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