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    Aniline derivatives, their manufacture and use as pharmaceutical agents
    1.
    发明授权
    Aniline derivatives, their manufacture and use as pharmaceutical agents 失效
    苯胺衍生物，其制造和用作药剂

    公开(公告)号：US07345067B2

    公开(公告)日：2008-03-18

    申请号：US10858297

    申请日：2004-06-01

    申请人： Jean Ackermann ,  Johannes Aebi ,  Alfred Binggeli ,  Uwe Grether ,  Georges Hirth ,  Bernd Kuhn ,  Hans-Peter Maerki ,  Markus Meyer ,  Peter Mohr ,  Matthew Blake Wright

    发明人： Jean Ackermann ,  Johannes Aebi ,  Alfred Binggeli ,  Uwe Grether ,  Georges Hirth ,  Bernd Kuhn ,  Hans-Peter Maerki ,  Markus Meyer ,  Peter Mohr ,  Matthew Blake Wright

    IPC分类号： A61K31/426 ,  C07D277/20

    CPC分类号： C07D277/28 ,  C07D263/32

    摘要： This invention relates to compounds of the formula wherein X is N and Y is S or O; or X is S or O and Y is N; R1 is hydrogen or C1-7-alkyl; R2 and R3 independently from each other are selected from the group consisting of hydrogen, C1-7-alkyl and C1-7-alkoxy; R4, R5, R6, and R7 independently from each other are selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl, halogen, C1-7-alkoxy, C1-7-alkyl-C1-7-alkoxy-C1-7-alkyl, C2-7-alkenyl, C2-7-alkinyl, fluoro-C1-7-alkyl and cyano; R8 is selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; R9 is selected from the group consisting of hydrogen, C1-7-alkyl, C2-7-alkinyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; R10 is selected from the group consisting of hydrogen, C1-7-alkyl, C2-7-alkinyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; R11 is aryl or heteroaryl; N is 0, 1 or 2; and all enantiomers and pharmaceutically acceptable salts and/or esters thereof and their use as PPAR activators.

    摘要翻译： 本发明涉及下式的化合物其中X是N，Y是S或O; 或X为S或O，Y为N; R 1是氢或C 1-7 - 烷基; R 2和R 3彼此独立地选自氢，C 1-7 - 烷基和C 1-4烷基， 1-7-烷氧基; R 4，R 5，R 6，R 6和R 7彼此独立地选自： 的氢，C 1-7 - 烷基，C 3-7 - 环烷基，卤素，C 1-7 - 烷氧基，C 烯基，C 2-7 - 炔基，氟-C 1-7 - 烷基和氰基; R 8选自氢，C 1-7 - 烷基，C 3-7 - 环烷基和氟-C 1-4烷基， 烷基; R 9选自氢，C 1-7 - 烷基，C 2-7 - 炔基，C 1〜 3-7环烷基和氟-C 1-7 - 烷基; R 10选自氢，C 1-7 - 烷基，C 2-7 - 炔基，C 1〜 3-7环烷基和氟-C 1-7 - 烷基; R 11是芳基或杂芳基; N为0,1或2; 及其所有对映异构体及其药学上可接受的盐和/或酯及其作为PPAR活化剂的用途。