An anti-rotation guide for a deactivation hydraulic valve lifter for an internal combustion engine. The guide includes a through bore accommodating of a hydraulic valve lifter and is sized such that the outer end of the lifter may be inserted into the through bore of the guide. The guide is securable to the engine such that the lifter is reciprocable within the guide. The guide is provided with two opposing keepers for mating with corresponding flats on the lifter to prevent rotation of the lifter. Further, a keyway means is provided in the guide and lifter to prevent the lifter being inserted into the guide 180° from the correct orientation.