发明授权
US07019151B2 Triptolide derivatives as immunomodulators and anticancer agents
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雷公藤内酯衍生物作为免疫调节剂和抗癌剂
- 专利标题： Triptolide derivatives as immunomodulators and anticancer agents
- 专利标题（中）： 雷公藤内酯衍生物作为免疫调节剂和抗癌剂
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申请号： US10738753申请日： 2003-12-16
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公开(公告)号： US07019151B2公开(公告)日： 2006-03-28
- 发明人: Dongcheng Dai , John H. Musser
- 申请人： Dongcheng Dai , John H. Musser
- 申请人地址： US CA Palo Alto
- 专利权人： Pharmagenesis, Inc.
- 当前专利权人： Pharmagenesis, Inc.
- 当前专利权人地址： US CA Palo Alto
- 代理机构： Perkins Coie LLP
- 代理商 LeeAnn Gorthey
- 主分类号： C07D307/93
- IPC分类号： C07D307/93
摘要：
Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R1 together with R2=O (oxo); R2=OH, or, R1 and R2 together=O (oxo); CR3R5 and CR4R6 are selected from CH2, CHOH and CROH; at least one of R1, R5 and R6 is R; and at least one of CR3R5 and CR4R6 is CH2.
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