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    Anti-arenaviral compounds
    1.
    发明授权
    Anti-arenaviral compounds 失效
    抗-nnaviral化合物

    公开(公告)号：US08518951B2

    公开(公告)日：2013-08-27

    申请号：US13338726

    申请日：2011-12-28

    申请人： Dennis E. Hruby ,  Tove C. Bolken ,  Dongcheng Dai

    发明人： Dennis E. Hruby ,  Tove C. Bolken ,  Dongcheng Dai

    IPC分类号： A61K31/4965

    CPC分类号： A61K31/496

    摘要： Described herein are 4-methyl-piperazine-1-carbothioic acid amide derivatives and analogs, as well as compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by hemorrhagic fever viruses, such as Arenaviruses.

    摘要翻译： 本文描述的是4-甲基 - 哌嗪-1-硫代羧酸酰胺衍生物和类似物以及含有它们的组合物，用于治疗或预防病毒感染和与之相关的疾病，特别是那些由出血热引起的病毒感染和相关疾病 病毒，如沙病毒属。

    Antiviral drugs for treatment of arenavirus infection
    4.
    发明授权
    Antiviral drugs for treatment of arenavirus infection 有权
    用于治疗斑马鱼病毒感染的抗病毒药物

    公开(公告)号：US08148428B2

    公开(公告)日：2012-04-03

    申请号：US12281081

    申请日：2007-03-02

    申请人： Dennis E. Hruby ,  Tove C. Bolken ,  Sean Amberg ,  Dongcheng Dai

    发明人： Dennis E. Hruby ,  Tove C. Bolken ,  Sean Amberg ,  Dongcheng Dai

    IPC分类号： A61K31/16

    CPC分类号： C07C251/86 ,  A61K31/165 ,  A61K31/343 ,  C07C251/76 ,  C07C251/82 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2603/20 ,  C07D209/40 ,  C07D307/68 ,  C07D333/22 ,  C07D333/38 ,  Y02A50/387 ,  Y02A50/397

    摘要： Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).

    摘要翻译： 公开了通过施用治疗有效量的某些新化合物来治疗病毒感染的化合物，方法和药物组合物。 还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。 特别地，公开了治疗和预防由出血热病毒引起的病毒感染，即，包括但不限于：链球菌科（Junin，Machupo，Guanarito，Sabia，Lassa，Tacaribe和Pichinde），丝状病毒科（埃博拉 马尔堡病毒），黄病毒科（黄热病，鄂木斯克出血热和Kyasanur森林病毒）和布尼瓦病毒（裂谷热）。

    Halogenated triptolide derivatives as immunomodulators and anticancer agents
    6.
    发明授权
    Halogenated triptolide derivatives as immunomodulators and anticancer agents 失效
    卤代雷公藤内酯衍生物作为免疫调节剂和抗癌剂

    公开(公告)号：US07417069B2

    公开(公告)日：2008-08-26

    申请号：US11210677

    申请日：2005-08-23

    申请人： Dongcheng Dai ,  John H. Musser

    发明人： Dongcheng Dai ,  John H. Musser

    IPC分类号： A61K31/36 ,  C07D493/14

    CPC分类号： C07D493/22

    摘要： Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C═O, CHF, CF2 and C(CF3)OH; CR6 and CR13 are selected from CH, COH and CF; CR7R8, CR9R10 and CR11R12 are selected from CH2, CHOH, C═O, CHF and CF2; and CR3R4R5 is selected from CH3, CH2OH, C═O, COOH, CH2F, CHF2 and CF3; such that: at least one of R1-R13 comprises fluorine; no more than two of CR3R4R5, CR6, CR7R8, CR9R10, CR11R12, and CR13 comprises fluorine or oxygen; and, when CR1R2 is CHOH, CR3R4R5 is not CH2F.

    摘要翻译： 具有结构I的化合物可用于诱导细胞死亡（凋亡）和免疫抑制。 在结构I中，CR 1，R 2选自CHOH，CO，CHF，CF 2和C（CF 3） OH）; CR 6和CR 13选自CH，COH和CF; R＆lt; 9＆gt; 8＆lt; 9＆gt;＆lt; 9＆lt; 10＆gt;和＆lt; 11＆gt; > 12 选自CH 2，CHOH，CO，CHF和CF 2; 和CR 3 R 4选自CH 3，CH 2，CH 2， OH，CO，COOH，CH 2，F，CHF 2和CF 3; 使得：R 1〜R 13中的至少一个包含氟; 不超过两个CR 3，R 4，R 5，CR 6，CR 7， 其中，R 8，R 9，R 10，R 11，R 12， 并且CR 13包括氟或氧; 当CR <1> 2 2时为CHOH时，CR 3 R 4 R 5 O >不是CH 2。

    Triptolide derivatives as immunomodulators and anticancer agents
    9.
    发明授权
    Triptolide derivatives as immunomodulators and anticancer agents 失效
    雷公藤内酯衍生物作为免疫调节剂和抗癌剂

    公开(公告)号：US07019151B2

    公开(公告)日：2006-03-28

    申请号：US10738753

    申请日：2003-12-16

    申请人： Dongcheng Dai ,  John H. Musser

    发明人： Dongcheng Dai ,  John H. Musser

    IPC分类号： C07D307/93

    CPC分类号： C07D493/22

    摘要： Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R1 is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R1 together with R2=O (oxo); R2=OH, or, R1 and R2 together=O (oxo); CR3R5 and CR4R6 are selected from CH2, CHOH and CROH; at least one of R1, R5 and R6 is R; and at least one of CR3R5 and CR4R6 is CH2.

    摘要翻译： 具有结构I的化合物可用于诱导细胞死亡（凋亡）和免疫抑制。 在结构I中，R 1是H或R，R选自低级烷基，烯基，炔基和烯丙基，或者R 1与R 2一起 O（氧代）; R 2 = OH，或R 1和R 2一起= O（氧代）; CH 3，R 5和R 4选自CH 2，CH 2， CHOH和CROH; R 1，R 5和R 6以及R 6中的至少一个为R; 并且CR 3和R 5中的至少一个是CH 2， SUB>。