发明授权
US07022337B2 Self-emulsifying formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability and/or reduced food effect
失效
非诺贝特和/或非诺贝特衍生物的自乳化制剂具有改善的口服生物利用度和/或降低的食物效应
- 专利标题： Self-emulsifying formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability and/or reduced food effect
- 专利标题（中）： 非诺贝特和/或非诺贝特衍生物的自乳化制剂具有改善的口服生物利用度和/或降低的食物效应
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申请号： US10607719申请日： 2003-06-27
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公开(公告)号： US07022337B2公开(公告)日： 2006-04-04
- 发明人: Likan Liang , Amir H. Shojaei , Scott A. Ibrahim , Beth A. Burnside
- 申请人： Likan Liang , Amir H. Shojaei , Scott A. Ibrahim , Beth A. Burnside
- 申请人地址： US MD Rockville
- 专利权人： Shire Laboratories, Inc.
- 当前专利权人： Shire Laboratories, Inc.
- 当前专利权人地址： US MD Rockville
- 代理商 Raj Bawa
- 主分类号： A61K9/48
- IPC分类号： A61K9/48
摘要：
A fibrate self-emulsifying oral formulation with improved bioavailability when compared to commercially available formulations containing a therapeutically effective dose of fenofibrate, derivative of fenofibrate or mixtures thereof dissolved in a fibrate solubilizer selected from N-alkyl derivative of 2-pyrrolidone, mono- or di- or polyethylene glycol monoethers, C8-12 fatty acid mono- or di-esters of propylene glycol, or combinations thereof, one or more surfactants and optionally one or more stabilizers useful in the treatment of hypercholesterolaemia or hypertriglyceridaemia in mammals in the fed or fasted state.
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