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US07022716B2 Cyclic amine phenyl beta-3 adrenergic receptor agonists 失效
环胺苯基β-3肾上腺素能受体激动剂

Cyclic amine phenyl beta-3 adrenergic receptor agonists
Abstract:
This invention provides compounds of Formula I having the structure wherein, R1, R2, R3, R4, R5, T, T1, T2, and X are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
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