发明授权
- 专利标题： Mesylates of piperazine derivatives and process for their preparation
- 专利标题（中）： 哌嗪衍生物的甲磺酸酯及其制备方法
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申请号： US10468098申请日： 2002-02-14
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公开(公告)号： US07030241B2公开(公告)日： 2006-04-18
- 发明人: Marcel P. M. van Aar , Stefanus J. Schouten , Jan Zorgdrager , Michiel C. Heslinga
- 申请人： Marcel P. M. van Aar , Stefanus J. Schouten , Jan Zorgdrager , Michiel C. Heslinga
- 申请人地址： NL Weesp
- 专利权人： Solvay Pharmaceuticals B.V.
- 当前专利权人： Solvay Pharmaceuticals B.V.
- 当前专利权人地址： NL Weesp
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 优先权： EP01200534 20010216
- 国际申请： PCT/EP02/01666 WO 20020214
- 国际公布： WO02/066449 WO 20020829
- 主分类号： C07D403/00
- IPC分类号： C07D403/00 ; C07D401/00 ; C07D405/00 ; C07D409/00
摘要：
The invention relates to the mesylates of a group of piperazine derivatives and to a process for the preparation of these mesylates in an economic way in the high yield and of high purity. According to the process of the invention the synthesis of the piperazine ring and the mesylate formation are combined in a single reaction step. The invention relates to the mesylate of compounds of the formula (I) wherein X is a bicyclic heterocyclic phenyl group and Y is methyl, ethyl (optionally substituted with fluorine), cycloalkyl (3–7C) methyl, benzyl or m-phenyl benzyl
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