- 专利标题: Method for the production of 1-amino-3-phenyluracil derivatives
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申请号: US10476941申请日: 2002-04-25
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公开(公告)号: US07034156B2公开(公告)日: 2006-04-25
- 发明人: Jörn Stölting , Dorothee Hoischen , Roland Andree , Karl-Heinz Linker , Holger Weintritt , Heinz-Jürgen Wroblowsky
- 申请人: Jörn Stölting , Dorothee Hoischen , Roland Andree , Karl-Heinz Linker , Holger Weintritt , Heinz-Jürgen Wroblowsky
- 申请人地址: DE Monheim
- 专利权人: Bayer CropScience AG
- 当前专利权人: Bayer CropScience AG
- 当前专利权人地址: DE Monheim
- 代理商 Richard E.L. Henderson
- 优先权: DE10122235 20010508
- 国际申请: PCT/EP02/04610 WO 20020425
- 国际公布: WO02/090338 WO 20021114
- 主分类号: C07D239/54
- IPC分类号: C07D239/54
摘要:
The present invention relates to a novel process for preparing known 1-amino-3-phenyluracil derivatives, to novel 1-amino-6-hydroxy-3-phenyldihydro-2,4(1H,3H)pyrimidinedione derivatives of the formula (II) in which R1 is hydrogen, cyano, nitro or halogen, R2 is cyano, nitro, halogen or optionally substituted alkyl or alkoxy, R3 is hydrogen, hydroxyl, mercapto, amino, hydroxyamino, hydrazino, halogen, or one of the radicals —R6, -Q-R6, —NH—R6, —NH—O—R6, —NH—SO2—R6, —N(SO2—R6)2, —CQ1-R6, —CQ1-Q2-R6, —CQ1-NH—R6, -Q2-CQ1-R6, —NH—CQ1-R6, —N(SO2—R6)(CQ1-R6), -Q2-CQ1-Q2-R6, —NH—CQ1-Q2-R6 or -Q2-CQ1-NH—R6, where Q is O, S, SO or SO2, Q1 and Q2 are each independently oxygen or sulphur and R6 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, R4 is hydrogen, halogen or optionally substituted alkyl, and R5 is fluorine- and/or chlorine-substituted alkyl, as intermediates for the 1-amino-3-phenyluracil derivatives, and to a process for preparing the intermediates.
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