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    Method for the production of 1-amino-3-phenyluracil derivatives
    1.
    发明授权
    Method for the production of 1-amino-3-phenyluracil derivatives 失效

    公开(公告)号：US07034156B2

    公开(公告)日：2006-04-25

    申请号：US10476941

    申请日：2002-04-25

    申请人： Jörn Stölting ,  Dorothee Hoischen ,  Roland Andree ,  Karl-Heinz Linker ,  Holger Weintritt ,  Heinz-Jürgen Wroblowsky

    发明人： Jörn Stölting ,  Dorothee Hoischen ,  Roland Andree ,  Karl-Heinz Linker ,  Holger Weintritt ,  Heinz-Jürgen Wroblowsky

    IPC分类号： C07D239/54

    CPC分类号： C07D239/22 ,  C07D239/54

    摘要： The present invention relates to a novel process for preparing known 1-amino-3-phenyluracil derivatives, to novel 1-amino-6-hydroxy-3-phenyldihydro-2,4(1H,3H)pyrimidinedione derivatives of the formula (II) in which R1 is hydrogen, cyano, nitro or halogen, R2 is cyano, nitro, halogen or optionally substituted alkyl or alkoxy, R3 is hydrogen, hydroxyl, mercapto, amino, hydroxyamino, hydrazino, halogen, or one of the radicals —R6, -Q-R6, —NH—R6, —NH—O—R6, —NH—SO2—R6, —N(SO2—R6)2, —CQ1-R6, —CQ1-Q2-R6, —CQ1-NH—R6, -Q2-CQ1-R6, —NH—CQ1-R6, —N(SO2—R6)(CQ1-R6), -Q2-CQ1-Q2-R6, —NH—CQ1-Q2-R6 or -Q2-CQ1-NH—R6, where Q is O, S, SO or SO2, Q1 and Q2 are each independently oxygen or sulphur and R6 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, R4 is hydrogen, halogen or optionally substituted alkyl, and R5 is fluorine- and/or chlorine-substituted alkyl, as intermediates for the 1-amino-3-phenyluracil derivatives, and to a process for preparing the intermediates.