发明授权
US07038075B2 Production method of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid C1-6 alkyl ester
失效
外消旋3-羟基-3-（2-苯基乙基）己酸C 1-6烷基酯的制备方法
- 专利标题： Production method of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid C1-6 alkyl ester
- 专利标题（中）： 外消旋3-羟基-3-（2-苯基乙基）己酸C 1-6烷基酯的制备方法
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申请号： US10727398申请日： 2003-12-04
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公开(公告)号： US07038075B2公开(公告)日： 2006-05-02
- 发明人: Masahide Tanaka , Kozo Matsui , Tadashi Katsura , Mitsuhiro Iwasaki , Hiroshi Maeda , Nobushige Itaya
- 申请人： Masahide Tanaka , Kozo Matsui , Tadashi Katsura , Mitsuhiro Iwasaki , Hiroshi Maeda , Nobushige Itaya
- 申请人地址： JP Tokyo
- 专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人地址： JP Tokyo
- 代理机构： Leydig, Voit & Mayer, Ltd.
- 优先权： JP2002-030724 20020207; JP2002-041480 20020219; JP2002-105772 20020408; JP2002-242741 20020822
- 主分类号： C07C69/66
- IPC分类号： C07C69/66
摘要：
The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII) wherein R2 is 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.
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