发明授权
- 专利标题： Indazole compounds useful as protein kinase inhibitors
- 专利标题（中）： 可用作蛋白激酶抑制剂的吲唑化合物
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申请号： US10350806申请日： 2003-01-23
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公开(公告)号： US07041687B2公开(公告)日： 2006-05-09
- 发明人: Hayley Binch , Guy Brenchley , Julian M. C. Golec , Ronald Knegtel , Michael Mortimore , Sanjay Patel , Alistair Rutherford
- 申请人： Hayley Binch , Guy Brenchley , Julian M. C. Golec , Ronald Knegtel , Michael Mortimore , Sanjay Patel , Alistair Rutherford
- 申请人地址： US MA Cambridge
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Cambridge
- 代理机构： Vertex Pharmaceuticals Incorporated
- 代理商 Lisa A. Dixon
- 主分类号： A61K31/41
- IPC分类号： A61K31/41
摘要：
The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein R1, R2, V1, V2, and V3 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT, PKA, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.
公开/授权文献
- US20040009968A1 Indazole compounds useful as protein kinase inhibitors 公开/授权日：2004-01-15
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