Invention Grant
- Patent Title: Oligonucleotides having alkylphosphonate linkages and methods for their preparation
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Application No.: US10163439Application Date: 2002-06-04
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Publication No.: US07049432B2Publication Date: 2006-05-23
- Inventor: Muthiah Manoharan , George Just , Andrei Guzaev , Arlène Roland , Jianchao Wang , Michael E. Jung
- Applicant: Muthiah Manoharan , George Just , Andrei Guzaev , Arlène Roland , Jianchao Wang , Michael E. Jung
- Applicant Address: US CA Carlsbad CA
- Assignee: ISIS Pharmaceuticals, Inc.,McGill University
- Current Assignee: ISIS Pharmaceuticals, Inc.,McGill University
- Current Assignee Address: US CA Carlsbad CA
- Agency: ISIS Paten Department Woodcock Washburn LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C07H21/00
Abstract:
The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure alkylphosphonate dimers are also provided.
Public/Granted literature
- US20030078414A1 Oligonucleotides having alkylphosphonate linkages and methods for their preparation Public/Granted day:2003-04-24
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