- 专利标题： Polynucleotides encoding a novel glycine receptor alpha subunit expressed in the gastrointestinal tract, HGRA4, and splice variant thereof
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申请号： US10075846申请日： 2002-02-13
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公开(公告)号： US07056737B2公开(公告)日： 2006-06-06
- 发明人: John N. Feder , Liana Lee , Jian Chen , Nathan O. Siemers , Han Chang
- 申请人： John N. Feder , Liana Lee , Jian Chen , Nathan O. Siemers , Han Chang
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Stephen C. D'Amico
- 主分类号： C12N5/00
- IPC分类号： C12N5/00
摘要：
The present invention provides novel polynucleotides encoding HGRA4 polypeptides, fragments and homologues thereof. The present invention also provides novel polynucleotides encoding a HGRA4 splice variant, HGRA4sv. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGRA4 and HGRA4sv polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
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