发明授权
US07063944B1 Human methionine synthase reductase: cloning, and methods for evaluating risk of, preventing, or treating neural tube defects, cardiovascular disease, cancer, and down's syndrome
失效
人甲硫氨酸合成酶还原酶：克隆和评估神经管缺陷，心血管疾病，癌症和衰老综合征的风险，预防或治疗的方法
- 专利标题： Human methionine synthase reductase: cloning, and methods for evaluating risk of, preventing, or treating neural tube defects, cardiovascular disease, cancer, and down's syndrome
- 专利标题（中）： 人甲硫氨酸合成酶还原酶：克隆和评估神经管缺陷，心血管疾病，癌症和衰老综合征的风险，预防或治疗的方法
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申请号： US09487841申请日： 2000-01-19
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公开(公告)号： US07063944B1公开(公告)日： 2006-06-20
- 发明人: Roy A. Gravel , Rima Rozen , Daniel Leclerc , Aaron Wilson , David Rosenblatt
- 申请人： Roy A. Gravel , Rima Rozen , Daniel Leclerc , Aaron Wilson , David Rosenblatt
- 申请人地址： CA Quebec
- 专利权人： McGill University
- 当前专利权人： McGill University
- 当前专利权人地址： CA Quebec
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12Q1/00 ; C12P19/34 ; C07H21/04
摘要：
The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, Down's Syndrome or cancer. The invention also features therapeutic methods for treating and/or reducing the risk of cardiovascular disease, Down's Syndrome, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.
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