利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

15 条记录 (耗时 0.032 秒)

    Human methionine synthase reductase: cloning, and methods for evaluating risk of, preventing, or treating neural tube defects, cardiovascular disease, cancer, and down's syndrome
    1.
    发明授权
    Human methionine synthase reductase: cloning, and methods for evaluating risk of, preventing, or treating neural tube defects, cardiovascular disease, cancer, and down's syndrome 失效
    人甲硫氨酸合成酶还原酶：克隆和评估神经管缺陷，心血管疾病，癌症和衰老综合征的风险，预防或治疗的方法

    公开(公告)号：US07063944B1

    公开(公告)日：2006-06-20

    申请号：US09487841

    申请日：2000-01-19

    申请人： Roy A. Gravel ,  Rima Rozen ,  Daniel Leclerc ,  Aaron Wilson ,  David Rosenblatt

    发明人： Roy A. Gravel ,  Rima Rozen ,  Daniel Leclerc ,  Aaron Wilson ,  David Rosenblatt

    IPC分类号： C12Q1/68 ,  C12Q1/00 ,  C12P19/34 ,  C07H21/04

    CPC分类号： C12N9/1007

    摘要： The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, Down's Syndrome or cancer. The invention also features therapeutic methods for treating and/or reducing the risk of cardiovascular disease, Down's Syndrome, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.

    摘要翻译： 本发明的特征在于一种编码甲硫氨酸合成酶还原酶的新基因。 本发明还特征在于一种用于检测高半胱氨酸血症的可能性增加的方法，反过来，增加或减少了神经管缺陷，心血管疾病，唐氏综合征或癌症的可能性。 本发明还具有用于治疗和/或降低心血管疾病唐氏综合征，癌症或神经管缺陷风险的治疗方法。 还提供了人甲硫氨酸合酶还原酶基因和蛋白质的序列，以及用于实施本发明方法的化合物和试剂盒。

    Human methionine synthase reductase: cloning, and methods for evaluating risk of neural tube deffects, cardiovascular disease, cancer and Down's Syndrome
    3.
    发明申请
    Human methionine synthase reductase: cloning, and methods for evaluating risk of neural tube deffects, cardiovascular disease, cancer and Down's Syndrome 审中-公开
    人甲硫氨酸合成酶还原酶：克隆和评估神经管的影响，心血管疾病，癌症和唐氏综合征风险的方法

    公开(公告)号：US20050191701A1

    公开(公告)日：2005-09-01

    申请号：US11119096

    申请日：2005-04-29

    申请人： Roy Gravel ,  Rima Rozen ,  Daniel Leclerc ,  Aaron Wilson ,  David Rosenblatt

    发明人： Roy Gravel ,  Rima Rozen ,  Daniel Leclerc ,  Aaron Wilson ,  David Rosenblatt

    IPC分类号： B60J7/10 ,  C12N9/10 ,  C12Q1/68

    CPC分类号： C12N9/1007

    摘要： The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, Down's Syndrome or cancer. The invention also features therapeutic methods for treating and/or reducing the risk of cardiovascular disease, Down's Syndrome, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.

    摘要翻译： 本发明的特征在于一种编码甲硫氨酸合成酶还原酶的新基因。 本发明还特征在于一种用于检测高半胱氨酸血症的可能性增加的方法，反过来，增加或减少了神经管缺陷，心血管疾病，唐氏综合征或癌症的可能性。 本发明还具有用于治疗和/或降低心血管疾病唐氏综合征，癌症或神经管缺陷风险的治疗方法。 还提供了人甲硫氨酸合酶还原酶基因和蛋白质的序列，以及用于实施本发明方法的化合物和试剂盒。

    Distributed resonant cavity light beam modulator
    4.
    发明授权
    Distributed resonant cavity light beam modulator 失效
    分布式谐振腔光束调制器

    公开(公告)号：US5157537A

    公开(公告)日：1992-10-20

    申请号：US650559

    申请日：1991-02-01

    申请人： David Rosenblatt

    发明人： David Rosenblatt

    IPC分类号： G02F1/01 ,  G02F1/015 ,  G02F1/03 ,  G02F3/02

    CPC分类号： G02F1/01 ,  G02F1/015 ,  G02F1/0338 ,  G02F2201/302 ,  G02F2202/101 ,  G02F2202/105 ,  G02F2203/01 ,  G02F2203/10 ,  G02F2203/12 ,  G02F2203/22 ,  G02F3/024

    摘要： An optical apparatus consisting of a laser for producing a coherent polarized beam of electromagnetic radiation of a preselected wavelength. A substrate of silicon has a first transparent cover layer for receiving the polarized beam substantially normally incident thereto, an a second transparent guide layer for receiving the polarized beam from said first layer and for supporting at least one resonant mode. The first and second layers have a preselected index of refraction and a grating is interposed between them, having a grating period less than half the preselected wavelength. The layers and grating interact to produce a standing wave resonance by Bragg reflection. A control obtains a resonance wavelength in the guide layer equal to the predetermined radiation wavelength and thereby high reflectance to modulate the polarized beam.

    摘要翻译： 一种由用于产生预选波长的电磁辐射的相干偏振光束的激光器组成的光学装置。 硅衬底具有用于接收基本上正常入射到其上的偏振光束的第一透明覆盖层，用于接收来自所述第一层的偏振光束并用于支持至少一个谐振模式的第二透明引导层。 第一层和第二层具有预选的折射率，并且在它们之间插入光栅，其光栅周期小于预选波长的一半。 层和光栅通过布拉格反射相互作用产生驻波共振。 控制器获得等于预定辐射波长的引导层中的共振波长，从而获得高反射率以调制偏振光束。

    Redox-active structures and devices utilizing the same
    5.
    发明授权
    Redox-active structures and devices utilizing the same 有权
    氧化还原活性结构和利用其的装置

    公开(公告)号：US08722879B2

    公开(公告)日：2014-05-13

    申请号：US11713800

    申请日：2007-03-05

    申请人： Milko E. Van Der Boom ,  Atindra D. Shukla ,  David Rosenblatt ,  Tarkeshwar Gupta

    发明人： Milko E. Van Der Boom ,  Atindra D. Shukla ,  David Rosenblatt ,  Tarkeshwar Gupta

    IPC分类号： C07D487/22

    CPC分类号： C07F15/0026 ,  C07F7/1804 ,  C07F15/0053 ,  G01N27/30 ,  G01N27/305 ,  G01N27/3275 ,  G01Q80/00 ,  G02F1/15 ,  H01G9/2018 ,  H01G9/2059 ,  H01L51/0002 ,  H01L51/0086 ,  H01L51/0088 ,  Y02E10/542 ,  Y02E10/549 ,  Y10T29/49002

    摘要： A device is presented having reversibly changeable and optically readable optical properties. The device comprises a substrate having an electrically conductive surface and carrying a redox-active layer structure. The redox-active layer structure may be a monolayer or a multi-layer structure and is configured to have at least one predetermined electronic property including at least one of electrodensity and oxidation state. The electronic property of the layer structure defines an optical property of the structure thereby determining an optical response of the structure to certain incident light. This at least one electronic property is changeable by subjecting the redox-active layer structure to an electric field or to a redox-active material. The device thus enables effecting a change in said electronic property that results in a detectable change in the optical response of the layer structure.

    摘要翻译： 呈现具有可逆变化和光学可读光学性质的装置。 该器件包括具有导电表面并承载氧化还原活性层结构的衬底。 氧化还原活性层结构可以是单层或多层结构，并且被配置为具有包括电密度和氧化态中的至少一种的至少一种预定的电子性质。 层结构的电子特性限定了该结构的光学特性，从而确定该结构对某些入射光的光响应。 通过使氧化还原活性层结构经受电场或氧化还原活性物质，该至少一种电子性质是可变化的。 因此，该装置能够实现导致层结构的光学响应的​​可检测变化的所述电子特性的变化。

    SYSTEMS AND METHODS FOR TRACKING PATENT RELATED INFORMATION
    6.
    发明申请
    SYSTEMS AND METHODS FOR TRACKING PATENT RELATED INFORMATION 审中-公开
    跟踪专利相关信息的系统和方法

    公开(公告)号：US20090327946A1

    公开(公告)日：2009-12-31

    申请号：US12415917

    申请日：2009-03-31

    申请人： Mark D. Stignani ,  David Rosenblatt ,  David Hendricksen ,  Samuel Goodrich

    发明人： Mark D. Stignani ,  David Rosenblatt ,  David Hendricksen ,  Samuel Goodrich

    IPC分类号： G06F3/048

    CPC分类号： G06Q10/10

    摘要： To facilitate faster, more efficient, and more effective extraction of information from patent file histories, the present inventors, devised among other things, systems and method for tracking changes to patent claims, specifications, and/or drawings that are shown in file wrappers. One exemplary system graphically displays the patent family and/or file wrapper timeline. Another reports information about a specific patent, an examiner, a technology area, and other patent related information that can be pulled from the file wrapper.

    摘要翻译： 为了促进从专利文件历史中更快，更有效和更有效地提取信息，本发明人设计了用于跟踪在文件包装器中示出的专利权利要求，规范和/或附图的变更的系统和方法。 一个示例性系统以图形方式显示专利族和/或文件包装器时间线。 另一个报告有关特定专利，审查员，技术领域和可从文件包装器中提取的其他专利相关信息的信息。

    Distributed resonant cavity light beam modulator
    10.
    发明授权
    Distributed resonant cavity light beam modulator 失效
    分布式谐振腔光束调制器

    公开(公告)号：US5337183A

    公开(公告)日：1994-08-09

    申请号：US963494

    申请日：1992-10-20

    申请人： David Rosenblatt

    发明人： David Rosenblatt

    IPC分类号： G02F1/01 ,  G02F1/015 ,  G02F1/03 ,  G02F3/02 ,  G02F1/07 ,  G02B1/10 ,  G02B27/44 ,  G02F1/035

    CPC分类号： G02F1/01 ,  G02F1/015 ,  G02F1/0338 ,  G02F2201/302 ,  G02F2202/101 ,  G02F2202/105 ,  G02F2203/01 ,  G02F2203/10 ,  G02F2203/12 ,  G02F2203/22 ,  G02F3/024

    摘要： An optical apparatus consisting of a laser for producing a coherent polarized beam of electromagnetic radiation of a preselected wavelength. A substrate of silicon has a first transparent cover layer for receiving the polarized beam substantially normally incident thereto, and a second transparent guide layer for receiving the polarized beam from the first layer and for supporting at least one resonant mode. The first and second layers have a preselected index of refraction and a grating is interposed between them, having a grating period less than half the preselected wavelength. The layers and grating interact to produce a standing wave resonance by Bragg reflection. A control obtains a resonance wavelength in the guide layer equal to the predetermined radiation wavelength and thereby high reflectance to modulate the polarized beam. The grating can be optimized for angular bandwidth by controlling the grating's Fourier components either in a single layer or in two grating layers which can also include a termination.

    摘要翻译： 一种由用于产生预选波长的电磁辐射的相干偏振光束的激光器组成的光学装置。 硅衬底具有用于接收基本上正常入射到其上的偏振光束的第一透明覆盖层和用于从第一层接收偏振光束并用于支持至少一个谐振模式的第二透明引导层。 第一层和第二层具有预选的折射率，并且在它们之间插入光栅，其光栅周期小于预选波长的一半。 层和光栅通过布拉格反射相互作用产生驻波共振。 控制器获得等于预定辐射波长的引导层中的共振波长，从而获得高反射率以调制偏振光束。 可以通过在单层或两个光栅层中控制光栅的傅立叶分量来对角度带宽进行优化，也可以包括终端。