- 专利标题： Compounds useful as modulators of Melanocortin Receptors and pharmaceutical compositions comprising same
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申请号： US10696761申请日： 2003-10-29
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公开(公告)号： US07067525B2公开(公告)日： 2006-06-27
- 发明人: Guixue Yu , John Macor , Timothy Herpin , R. Michael Lawrence , George C. Morton , Rejean Ruel , Graham S. Poindexter , Edward H. Ruediger , Carl Thibault
- 申请人： Guixue Yu , John Macor , Timothy Herpin , R. Michael Lawrence , George C. Morton , Rejean Ruel , Graham S. Poindexter , Edward H. Ruediger , Carl Thibault
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Co.
- 当前专利权人： Bristol-Myers Squibb Co.
- 当前专利权人地址： US NJ Princeton
- 代理商 Laurelee A. Duncan
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/445 ; C07D401/04 ; C07D413/04 ; C07D211/70
摘要：
Compounds having the formula (I), G is a novel side chain selected from C2-6alkenyl, A3-aryl, —OR18, heteroaryl, A1-cyano, A2—OR17, A1—C(═O)R18, A1—CO2R18, A1—C(═O)NR18R19, A1—OC(═O)R18, A1—NR18C(═O)R19, A1—OC(═O)NR18R19, A1—NR18CO2R19, A1—NR18SO2R17, A1—SO2R17, A1—NR20C(═O)NR18R19, and A1—SR18; or when y is 0 or when W is not NHR22, G may be A1-heterocyclo, wherein A1 is a bond, C1-6alkylene or C2-alkenylene, A2 is C1-6alkylene or C2-6alkenylene, and A3 is C2-6alkenylene; W is selected from —NR21R22, —OR23, —NR21C(═O)R24, —NR21CO2R24, amidino, guanidino, or a heteroaryl, heterocyclo or C3-7cycloalkyl as defined in the specification, and X and R1 through R24 are as defined in the specification, are effective as modulators of melanocortin-receptors, particularly MC-1R and MC-4R.
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