发明授权
US07074594B2 Guanosine triphosphate (GTP) binding protein-coupled receptor proteins
失效
鸟苷三磷酸（GTP）结合蛋白偶联受体蛋白
- 专利标题： Guanosine triphosphate (GTP) binding protein-coupled receptor proteins
- 专利标题（中）： 鸟苷三磷酸（GTP）结合蛋白偶联受体蛋白
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申请号： US10759463申请日： 2004-01-16
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公开(公告)号： US07074594B2公开(公告)日： 2006-07-11
- 发明人: Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
- 申请人： Hiraku Itadani , Tetsuo Takimura , Takao Nakamura , Masahiko Kobayashi , Ken-Ichi Tanaka , Yusuke Hidaka , Masataka Ohta
- 申请人地址： JP Tokyo
- 专利权人： Banyu Pharmaceutical Co., Ltd.
- 当前专利权人： Banyu Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Fish & Richardson P.C.
- 优先权： JPPCT/JP98/05967 19981225; JP11/145661 19990525
- 主分类号： C01K15/12
- IPC分类号： C01K15/12
摘要：
A full-length cDNA encoding a human-derived G protein-coupled receptor protein is isolated by screening a human hippocampus library. Also, a rat-derived cDNA corresponding to the human-derived cDNA is isolated. Proteins encoded by these cDNAs have an activity of lowering intracellular cAMP concentration under stimulation with histamine. These proteins are usable as tools in screening ligands thereof or in screening candidate compounds for drugs capable of regulating signal transduction from the above proteins.