发明授权
US07074923B2 Process for preparing xanthine phosphodiesterase V inhibitors and precursors thereof
失效
黄嘌呤磷酸二酯酶V抑制剂及其前体的制备方法
- 专利标题: Process for preparing xanthine phosphodiesterase V inhibitors and precursors thereof
- 专利标题(中): 黄嘌呤磷酸二酯酶V抑制剂及其前体的制备方法
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申请号: US10449526申请日: 2003-05-30
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公开(公告)号: US07074923B2公开(公告)日: 2006-07-11
- 发明人: Vilas A. Dahanukar , Hoa N. Nguyen , Cecilia A. Orr , Fucheng Zhang , Ilia A. Zavialov
- 申请人: Vilas A. Dahanukar , Hoa N. Nguyen , Cecilia A. Orr , Fucheng Zhang , Ilia A. Zavialov
- 申请人地址: US NJ Keniworth
- 专利权人: Schering Corporation
- 当前专利权人: Schering Corporation
- 当前专利权人地址: US NJ Keniworth
- 代理商 H. Eric Fischer; Gerard E. Reinhardt
- 主分类号: C07D473/08
- IPC分类号: C07D473/08 ; C07D473/06 ; C07D233/90
摘要:
A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations, a dihalogenation step to synthesize Compound 7, and a coupling reaction to produce Compound 9