发明授权
US07081463B2 Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders
有权
用于治疗orl-1受体介导的疾病的羟基烷基取代的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物
![Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders](/docs/US/2006-07-25/US07081463B2/abs.jpg.600x600.jpg)
- 专利标题： Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders
- 专利标题（中）： 用于治疗orl-1受体介导的疾病的羟基烷基取代的1,3,8-三氮杂螺[4.5]癸-4-酮衍生物
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申请号： US10656934申请日： 2003-09-05
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公开(公告)号： US07081463B2公开(公告)日： 2006-07-25
- 发明人: Kathleen Battista , Gilles Bignan , Peter J. Connolly , Allen B. Reitz , Tina Morgan Ross , Malcolm Scott , Steven A. Middleton , Michael Orsini
- 申请人： Kathleen Battista , Gilles Bignan , Peter J. Connolly , Allen B. Reitz , Tina Morgan Ross , Malcolm Scott , Steven A. Middleton , Michael Orsini
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人地址： BE Beerse
- 代理商 Hal B. Woodrow
- 主分类号： H61K31/438
- IPC分类号： H61K31/438 ; C07D401/04
![Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders](/abs-image/US/2006/07/25/US07081463B2/abs.jpg.150x150.jpg)
摘要：
The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain, migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.
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